Results 51 to 60 of about 166,756 (292)

SORABE NUMÉRIQUES? ENJEUX ET PERSPECTIVES D’ÉTUDE DES MANUSCRITS ARABICO-MALGACHES À TRAVERS LE CAS D’UN FONDS NUMÉRIQUE INÉDIT [PDF]

open access: yesAsian and African Studies
This article is an expanded version of a paper delivered at the FHA International Conference in Tunis-Carthage (13t-15t April 2023). The purpose of this contribution is to analyse the impact that the global trend of the digitization of knowledge can ...
Silvia Neposteri
doaj   +1 more source

The Use of Machine Learning in Volatility: A Review Using K-Means

open access: yesUniversidad y Empresa, 2023
Recently, the use of machine learning (ML) in scientific disciplines has experienced an unprecedented increase. Finance has not been an exception. Several works have been published in recent years using ml techniques. However, one of the topics with the
Jesus Enrique Molina Muñoz   +1 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Bishops as Cultural Mediators in Medieval Armenia: Their Role in the Production and Circulation of Manuscripts

open access: yes, 2022
In addition to their liturgical duties and their role as community leaders, Armenian bishops were deeply involved in the preservation, transmission and development of the national culture.
Van Elverdinghe, Emmanuel   +1 more
core  

“Why We Say No! A Look Through the Editor’s Eye” [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2015
Background: The rapidly flourishing health science has provided a ground to perform research work and contribute to the field of science. On the other hand, reporting the research is equally important as carrying out research. Many such researches and
Aarti Garg, Sunanda Das, Hemant Jain
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Authorship practices and experiences in a South African Faculty of Health Sciences

open access: yesResearch Ethics Review
Authorship remains a topic of discussion despite clear recommendations by the International Committee for Medical Journal Editors (ICMJE) adhered to by many publications from health sciences disciplines.
Gina Joubert, Cornel van Rooyen
doaj   +1 more source

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