Results 41 to 50 of about 172,422 (234)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Many-objective ant lion optimizer (MaOALO): A new many-objective optimizer with its engineering applications

Heliyon
Many-objective optimization (MaO) is an important aspect of engineering scenarios. In many-objective optimization algorithms (MaOAs), a key challenge is to strike a balance between diversity and convergence. MaOAs employs various tactics to either enhance selection pressure for better convergence and/or implements additional measures for sustaining ...
Kanak Kalita, Sundaram B. Pandya, Robert Čep, Pradeep Jangir, Laith Abualigah   +4 more
openaire   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Two reference vector sets based evolutionary algorithm for many‐objective optimization

IET Control Theory & Applications, 2023
Solving many‐objective optimization problems (MaOPs) by means of evolutionary algorithms obtains considerable attention in the community of evolutionary computation.
Cifeng Qin, Fei Ming, Wenyin Gong
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

An Integral Cybersecurity Approach Using a Many-Objective Optimization Strategy

IEEE Access, 2023
Data networks and computing devices have experienced exponential growth. Within a short span of time, they have opened new digital frontiers while also bringing forth new threats.
Omar Salinas, Ricardo Soto, Broderick Crawford, Rodrigo Olivares   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An Inhomogeneous Grid-Based Evolutionary Algorithm for Many-Objective Optimization

IEEE Access, 2022
Today, many-objective optimization problems have attracted widespread attention. There are significant advantages of the grid-based algorithm in solving multi-objective problems. Grid-based algorithm could offer a transformation of objectives and further
Maowei He, Haitao Xia, Hanning Chen, Lianbo Ma   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Research on optimization method of reconnaissance constellation based on multi-objective evolutionary algorithm [PDF]

Zhihui kongzhi yu fangzhen
In order to further solve the optimization problem of reconnaissance constellation and strengthen the construction of space-based reconnaissance system, the current optimization methods of reconnaissance constellation are studied and summarized.
LIU Yali, XIONG Wei
doaj   +1 more source