Results 61 to 70 of about 172,422 (234)

A Simplified Hypervolume-Based Evolutionary Algorithm for Many-Objective Optimization

Complexity, 2020
Evolutionary algorithms based on hypervolume have demonstrated good performance for solving many-objective optimization problems. However, hypervolume needs prohibitively expensive computational effort.
Hong Ji, Cai Dai
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

History Matching Reservoir Models With Many Objective Bayesian Optimization

Applied AI Letters
Reservoir models for predicting subsurface fluid and rock behaviors can now include upwards of billions (and potentially trillions) of grid cells and are pushing the limits of computational resources.
Steven Samoil, Clyde Fare, Kirk E. Jordan, Zhangxin Chen   +3 more
doaj   +1 more source

Convergence-Driven Adaptive Many-Objective Particle Swarm Optimization

IEEE Access
In recent years, the prevalence of Many-Objective Optimization Problems (MaOPs) in practical applications has been increasing. However, traditional multi-objective optimization algorithms, such as Multiple Objective Particle Swarm Optimization (MOPSO ...
Yunfei Yi, ZhiYong Wang, Yunying Shi, Zhengzhuo Song, Binbin Zhao   +4 more
doaj   +1 more source

Comparison of evolutionary algorithms applied to optimal design of water distribution networks [PDF]

RBRH
The pursuit of efficient water distribution network (WDN) projects that reflect the complexities of real systems has spurred the development and application of various optimization techniques.
Renata Sayuri Muranaka, Jonas Soares Rangel, Marcelo Antonio Marotta, Alexandre Kepler Soares   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Benchmarking Real-World Many-Objective Problems: A Problem Suite With Baseline Results

IEEE Access
In recent decades, multi-objective evolutionary algorithms (MOEAs) have been evaluated on artificial test problems with unrealistic characteristics, leading to uncertain conclusions about their efficacy in real-world applications.
Vikas Palakonda, Jae-Mo Kang, Heechul Jung   +2 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source