Results 81 to 90 of about 172,422 (234)

Multi-and many-objective optimization: present and future in de novo drug design. [PDF]

Front Chem, 2023
Angelo JS, Guedes IA, Barbosa HJC, Dardenne LE.   +3 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Weight Vector Definition for MOEA/D-Based Algorithms Using Augmented Covering Arrays for Many-Objective Optimization

Mathematics
Many-objective optimization problems are today ever more common. The decomposition-based approach stands out among the evolutionary algorithms used for their solution, with MOEA/D and its variations playing significant roles.
Carlos Cobos, Cristian Ordoñez, Jose Torres-Jimenez, Hugo Ordoñez, Martha Mendoza   +4 more
doaj   +1 more source

A Dual-Population-Based NSGA-III for Constrained Many-Objective Optimization. [PDF]

Entropy (Basel), 2022
Geng H, Zhou Z, Shen J, Song F.
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Dynamic Objective Sampling in Many-objective Optimization

Procedia Computer Science, 2015
AbstractGiven the poor convergence of multi-objective evolutionary algorithms (MOEAs) demonstrated in several studies that address many-objective optimization, we propose a simple objective sampling scheme that can be incorporated in any MOEA in order to enhance its convergence towards the Pareto front.
Breaban, Mihaela Elena, Iftene, Adrian
openaire   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Integrating transformers and many-objective optimization for drug design

BMC Bioinformatics
Background Drug design is a challenging and important task that requires the generation of novel and effective molecules that can bind to specific protein targets.
Nicholas Aksamit, Jinqiang Hou, Yifeng Li, Beatrice Ombuki-Berman   +3 more
doaj   +1 more source

A Reference Point-Based Evolutionary Algorithm Solves Multi and Many-Objective Optimization Problems: Method and Validation. [PDF]

Comput Intell Neurosci, 2023
Jameel M, Abouhawwash M.
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source