Results 41 to 50 of about 75,350 (240)

Convergence-Driven Adaptive Many-Objective Particle Swarm Optimization

IEEE Access
In recent years, the prevalence of Many-Objective Optimization Problems (MaOPs) in practical applications has been increasing. However, traditional multi-objective optimization algorithms, such as Multiple Objective Particle Swarm Optimization (MOPSO ...
Yunfei Yi, ZhiYong Wang, Yunying Shi, Zhengzhuo Song, Binbin Zhao   +4 more
doaj   +1 more source

MaOSSA: A new high-efficiency many-objective salp swarm algorithm with information feedback mechanism for industrial engineering problems

Results in Engineering
The pursuit of convergence in multi-objective optimization usually results in population clustering that produces suboptimal outcomes for both convergence and diversity performance.
Mohammad Aljaidi, Janjhyam Venkata Naga Ramesh, Ajmeera Kiran, Pradeep Jangir, Arpita, Sundaram B. Pandya, Wulfran Fendzi Mbasso, Laith Abualigah, Ali Fayez Alkoradees, Mohammad Khishe   +9 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Benchmarking Real-World Many-Objective Problems: A Problem Suite With Baseline Results

IEEE Access
In recent decades, multi-objective evolutionary algorithms (MOEAs) have been evaluated on artificial test problems with unrealistic characteristics, leading to uncertain conclusions about their efficacy in real-world applications.
Vikas Palakonda, Jae-Mo Kang, Heechul Jung   +2 more
doaj   +1 more source

Test Problems for Large-Scale Multiobjective and Many-Objective Optimization

IEEE Transactions on Cybernetics, 2017
The interests in multiobjective and many-objective optimization have been rapidly increasing in the evolutionary computation community. However, most studies on multiobjective and many-objective optimization are limited to small-scale problems, despite the fact that many real-world multiobjective and many-objective optimization problems may involve a ...
Ran Cheng, Yaochu Jin, Markus Olhofer, Bernhard sendhoff   +3 more
openaire   +5 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Solving Many-Objective Optimization Problems via Multistage Evolutionary Search

IEEE Transactions on Systems, Man, and Cybernetics: Systems, 2021
With the increase in the number of optimization objectives, balancing the convergence and diversity in evolutionary multiobjective optimization becomes more intractable. So far, a variety of evolutionary algorithms have been proposed to solve many-objective optimization problems (MaOPs) with more than three objectives.
Huangke Chen, Ran Cheng, Witold Pedrycz, Yaochu Jin   +3 more
openaire   +4 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source