Results 111 to 120 of about 15,152,741 (289)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Workshop Proceedings Many Strong Voices Stakeholder Workshop [PDF]
, 2007 This document offers summaries of presentations and discussions held during the workshop.
Many Strong Voices, -
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Lieutenant James B. Many, 2nd Regiment, Pittsburgh
Many acknowledges receiving a flat bottom boat and supplies to be delivered to Wilkinsonville from Deputy Quartermaster Isaac Craig.Contemporary ...
Many, James B.
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Optimizing Queries with Many-to-Many Joins
2025 IEEE 41st International Conference on Data Engineering (ICDE)As database query processing techniques are being used to handle diverse workloads, a key emerging challenge is how to efficiently handle multi-way join queries containing multiple many-to-many joins. While uncommon in traditional enterprise settings that have been the focus of much of the query optimization work to date, such queries are seen ...
Hasara Kalumin, Amol Deshpande
openaire +4 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Many Worlds, Many Theories, Many Rules: Formulating an Ethical System for the World to Come
Revista Brasileira de Política InternacionalThere are many ways to speak about the modern world, and many theories setting it apart. I focus on a world facing economic decline and a return to the status-ordering of traditional societies. With republican theory as a backdrop, I show that an updated
Nicholas Onuf
doaj +1 more source