Results 221 to 230 of about 649,548 (363)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Phospho-Proteomics Identifies D-Group MAP Kinases as Substrates of the <i>Arabidopsis</i> Tyrosine Phosphatase RLPH2. [PDF]

Plant Direct
Labandera AM, Toth R, Mitchell S, Johnson JJ, Kurucz B, Puyaubert J, Baudouin E, Uhrig RG, Moorhead GB.   +8 more
europepmc   +1 more source

The mRNA decay factor PAT 1 functions in a pathway including MAP kinase 4 and immune receptor SUMM 2

, 2015
Milena Roux, Magnus Wohlfahrt Rasmussen, Kristoffer Palma, Signe Lolle, Àngels Mateu‐Regué, Gerit Bethke, Jane Glazebrook, Weiping Zhang, Leslie Sieburth, Martin R. Larsen, John Mundy, Morten Petersen   +11 more
openalex   +1 more source

Supplementary Table 4 from MAP Kinase Pathway Alterations in <i>BRAF</i>-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

, 2023
Nikhil Wagle, Eliezer M. Van Allen, Daniel J. Treacy, Dennie T. Frederick, Zachary A. Cooper, Amaro Taylor‐Weiner, Mara Rosenberg, Eva M. Goetz, Ryan J. Sullivan, Deborah Farlow, Dennis C. Friedrich, Kristin Anderka, Danielle Perrin, Cory M. Johannessen, Aaron McKenna, Kristian Cibulskis, Gregory V. Kryukov, Eran Hodis, Donald P. Lawrence, Sheila Fisher, Gad Getz, Stacey Gabriel, Scott L. Carter, Keith T. Flaherty, Jennifer A. Wargo, Levi A. Garraway   +25 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Curation of the Fasciola hepatica kinome as a resource for drug target discovery. [PDF]

BMC Genomics
Ajmera S, Puckelwaldt O, Stroehlein AJ, Haeberlein S.   +3 more
europepmc   +1 more source

Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components.

Biochemical Journal, 2000
J. Schuringa, L. Jonk, W. Dokter, E. Vellenga, W. Kruijer   +4 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5. [PDF]

Front Immunol
Yang B, Fang G, Marx I, Liu G, Skouras S, Sharma K, Walther DM, Bollinger Martinez S, Hubeau C, Shi Y, De Savi C, Huang X, Huhn A, Sawant R, Proctor WR, Dixit VS, Dong H, Weiss MM, Mainolfi N, Slavin A, Long AJ, Williams JA, Byrne FR.   +22 more
europepmc   +1 more source

Role of MEKK2-MEK5 in the regulation of TNF-α gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells

Proceedings of the National Academy of Sciences of the United States of America, 2001
K. Chayama, P. Papst, T. Garrington, J. C. Pratt, T. Ishizuka, Saiphone Webb, Soula Ganiatsas, L. Zon, Weiyong Sun, G. Johnson, E. Gelfand   +10 more
semanticscholar   +1 more source