Results 331 to 340 of about 649,548 (363)

GmMKK4-activated GmMPK6 stimulates GmERF113 to trigger resistance to Phytophthora sojae in soybean.

The Plant Journal, 2022
Phytophthora root and stem rot is a worldwide soybean disease caused by the soil-borne pathogen Phytophthora sojae. This disease is devastating to soybean (Glycine max) production, so improvement of resistance to P.
Hong-bo Gao, Liangyu Jiang, Banghan Du, Bin Ning, Xiaodong Ding, Chuanzhong Zhang, Bo Song, Shanshan Liu, Ming Zhao, Yuxin Zhao, Tianyu Rong, Dongxue Liu, Jun-jiang Wu, P. Xu, Shuzhen Zhang   +14 more
semanticscholar   +1 more source

p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts

American Journal of Physiology-Endocrinology and Metabolism, 2003
We previously reported that p70 S6 kinase takes part in bone morphogenetic protein-4 (BMP-4)-stimulated vascular endothelial growth factor (VEGF) synthesis in osteoblast-like MC3T3-E1 cells. Recently, we showed that BMP-4-induced osteocalcin synthesis is regulated by p44/p42 MAP kinase and p38 MAP kinase in these cells.
Haruhiko, Tokuda, Daijiro, Hatakeyama, Toshiyuki, Shibata, Shigeru, Akamatsu, Yutaka, Oiso, Osamu, Kozawa   +5 more
openaire   +2 more sources

Structure‐based investigation of MARK4 inhibitory potential of Naringenin for therapeutic management of cancer and neurodegenerative diseases

Journal of Cellular Biochemistry, 2021
MAP/microtubule affinity‐regulating kinase 4 (MARK4) is a member of serine/threonine kinase family and considered an attractive drug target for many diseases.
Saleha Anwar, Shama Khan, Anas Shamsi, F. Anjum, Alaa Shafie, A. Islam, F. Ahmad, M. Hassan   +7 more
semanticscholar   +1 more source

Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein‐4‐stimulated osteocalcin synthesis in osteoblasts

Journal of Cellular Biochemistry, 2002
AbstractIn the present study, we investigated whether the mitogen‐activated protein (MAP) kinase superfamily is involved in the bone morphogenetic protein (BMP)‐4‐stimulated synthesis of osteocalcin in osteoblast‐like MC3T3‐E1 cells. BMP‐4 dose‐dependently stimulated osteocalcin synthesis.
Osamu, Kozawa, Daijiro, Hatakeyama, Toshihiko, Uematsu   +2 more
openaire   +2 more sources

SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2000
The 4-hydroxypiperidine substituent was found to confer high p38 selectivity devoid of COX-1 affinity, when attached to a series of pyridinyl substituted heterocycles. Pyridinyloxazole 11 showed a promising in vivo profile with bioavailability of 64% and ED50 in rat collagen induced arthritis of 10 mg/kg po bid.
L, Revesz, F E, Di Padova, T, Buhl, R, Feifel, H, Gram, P, Hiestand, U, Manning, A G, Zimmerlin   +7 more
openaire   +2 more sources

Structural and signaling requirements of the human melanocortin 4 receptor for MAP kinase activation

Regulatory Peptides, 2007
In addition to its well known stimulation of cAMP production, the human melanocortin type 4 (hMC4) receptor recently has been shown to mediate p44/42 MAPK activation. This finding opens new questions about the structural and signaling mechanisms that connect the receptor to this alternate cell signaling pathway.
Caroline S, Patten, Derek, Daniels, Aae, Suzuki, Steven J, Fluharty, Daniel K, Yee   +4 more
openaire   +2 more sources

Effects of the Mitogen-Activated Protein (MAP) Kinase Kinase Inhibitor 2-(2′-Amino-3′-methoxyphenyl)-oxanaphthalen-4-one (PD98059) on Human Platelet Activation

Biochemical Pharmacology, 1998
The role of mitogen-activated protein (MAP) kinase cascades in platelet function remains to be determined. Several studies have suggested a role in the activation of phospholipase A2; however, other functions seem likely. The object of the present study was to determine the role of the MAP kinase cascade in platelet function.
A, McNicol, C L, Philpott, T S, Shibou, S J, Israels   +3 more
openaire   +2 more sources

2‐Acylaminopyridin‐4‐ylimidazoles as p38 MAP Kinase Inhibitors: Design, Synthesis, and Biological and Metabolic Evaluations

ChemMedChem, 2009
AbstractTargeting cytokines has become an important focus in the treatment of many inflammatory disorders. p38 MAP kinase (MAPK) is the key enzyme in regulating the biosynthesis and release of pro‐inflammatory cytokines such as IL‐1β and TNFα. Inhibition of p38 MAPK results in decreased expression of these cytokines.
Katharina, Ziegler, Dominik R J, Hauser, Anke, Unger, Wolfgang, Albrecht, Stefan A, Laufer   +4 more
openaire   +2 more sources

The Hordeum vulgare signalling protein MAP kinase 4 is a regulator of biotic and abiotic stress responses

Journal of Plant Physiology, 2013
Mitogen activated protein kinase (MAP kinase) signal transduction pathways are important eukaryotic mechanisms for regulating cellular responses to stress. The objective of this work was to investigate the role of the barley MAP kinase HvMPK4 (a homologue of the Arabidopsis MAP kinase AtMPK1) in the plant response to biotic and abiotic stress ...
Mohammed, Abass, Peter C, Morris
openaire   +2 more sources