Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase [PDF]
BMC Neuroscience, 2003 Background G protein-coupled receptors (GPCRs) interact with heterotrimeric GTP-binding proteins (G proteins) to modulate acute changes in intracellular messenger levels and ion channel activity.
Guan Kunliang +7 more
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MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis [PDF]
Frontiers in Immunology, 2021 Cardiac fibrosis, a pathological condition due to excessive extracellular matrix (ECM) deposition in the myocardium, is associated with nearly all forms of heart disease.
Chao Zhong +20 more
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HAM-5 functions as a MAP kinase scaffold during cell fusion in Neurospora crassa. [PDF]
PLoS Genetics, 2014 Cell fusion in genetically identical Neurospora crassa germlings and in hyphae is a highly regulated process involving the activation of a conserved MAP kinase cascade that includes NRC-1, MEK-2 and MAK-2. During chemotrophic growth in germlings, the MAP
Wilfried Jonkers +8 more
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MAP Kinase Phosphatase-5 Deficiency Improves Endurance Exercise Capacity [PDF]
CellsAerobic exercise promotes physiological cardiac adaptations, improving cardiovascular function and endurance exercise capacity. However, the molecular mechanisms by which aerobic exercise induces cardiac adaptations and enhances endurance performance ...
Jaime A. Perales +5 more
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Stress Activated MAP Kinases and Cyclin-Dependent Kinase 5 Mediate Nuclear Translocation of Nrf2 via Hsp90α-Pin1-Dynein Motor Transport Machinery [PDF]
Antioxidants, 2023 Non-lethal low levels of oxidative stress leads to rapid activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which upregulates the expression of genes important for detoxification, glutathione synthesis, and defense against ...
Tetsuro Ishii +2 more
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The ? phosphorylase kinase gene, Phkg, maps to mouse Chromosome 5 near Gus [PDF]
Mammalian Genome, 1994 Phosphorylase kinase is a multimeric regulatory enzyme in the glycogenolytic pathway. Interest in various types of phosphorylase kinase enzyme deficiency has focused attention on cloning and mapping the enzyme subunits. We report the mapping of the catalytic gamma subunit gene, Phkg, to mouse Chromosome (Chr) 5 near beta-glucuronidase (Gus), between ...
Andrea J. Maichele +1 more
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IL-5 activates a 45-kilodalton mitogen-activated protein (MAP) kinase and Jak-2 tyrosine kinase in human eosinophils. [PDF]
The Journal of Immunology, 1996 Abstract IL-5 is a member of the hemopoietic cytokine family and has profound effects on the differentiation, survival, migration, and effector function of human eosinophils. Increased tyrosine phosphorylation has been observed as an early event in IL-5 signal transduction in eosinophils; most notably, proteins of 45 and 135 kDa became ...
Mary Ellen Bates +2 more
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Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase
Bioorganic & Medicinal Chemistry Letters, 2010 The synthesis, structure-activity relationship and modeling of a series of 5-substituted-N-aryl pyridazinone based p38alpha inhibitors are described. In comparing the series to the similar N-aryl pyridinone series, it was found that the pyridazinones maintained a weaker interaction to the p38 enzyme, and therefore showed generally weaker binding than ...
Kevin D. Jerome +7 more
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Map kinase phosphatase 5 protects against sepsis-induced acute lung injury
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2012 Mitogen-activated protein kinases (MAPKs) play a critical role in inflammation. Although activation of MAPK in inflammatory cells has been studied extensively, much less is known about the inactivation of these kinases. MAPK phosphatase 5 (MKP5) is a member of the dual-specificity phosphatase family that dephosphorylates activated MAPKs.
Feng Qian +6 more
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A novel function for the MAP kinase SMA-5 in intestinal tube stability
Molecular Biology of the Cell, 2016 Intermediate filaments are major cytoskeletal components whose assembly into complex networks and isotype-specific functions are still largely unknown. Caenorhabditis elegans provides an excellent model system to study intermediate filament organization and function in vivo.
Florian Geisler +7 more
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