Results 191 to 200 of about 274,417 (276)

FcR γ-chain and platelet hyperactivity. [PDF]

Blood Adv
Silverstein RL.
europepmc   +1 more source

Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases

, 2010
Chunjian Liu, James C. Lin, Stephen T. Wrobleski, Shuqun Lin, John Hynes, Hong Wu, Alaric J. Dyckman, Tianle Li, John Wityak, Kathleen M. Gillooly, Sidney Pitt, Ding Ren Shen, Rosemary F. Zhang, Kim W. McIntyre, Luisa Salter–Cid, David J. Shuster, Hongjian Zhang, Punit H. Marathe, Arthur M. Doweyko, John S. Sack, Susan E. Kiefer, Kevin Kish, John A. Newitt, Murray McKinnon, John H. Dodd, Joel C. Barrish, Gary L. Schieven, Katerina Leftheris   +27 more
openalex   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

CIT kinase phosphorylation as significant regulatory node for cellular checkpoints. [PDF]

Front Bioinform
Thomas J, Lubaba F, Ahmed M, Mahin A, John L, Gopalakrishnan AP, Subair S, Shivamurthy PB, Raju R, Soman S.   +9 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Phenylamino-Substituted 6,11-Dihydro-dibenzo[b,e]oxepin-11-ones and Dibenzo[a,d]cycloheptan-5-ones:  Novel p38 MAP Kinase Inhibitors

, 2006
Stefan Laufer, Gabriele M. Ahrens, Solveigh C. Karcher, Jörg S. Hering, Raimund Nieß   +4 more
openalex   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Inhibitors supercharge kinase turnover through native proteolytic circuits. [PDF]

Nature
Scholes NS, Bertoni M, Comajuncosa-Creus A, Kladnik K, Guo X, Frommelt F, Hinterndorfer M, Razumkov H, Prokofeva P, Schwalm MP, Born F, Roehm S, Imrichova H, Santini BL, Barone E, Schätz C, Muñoz I Ordoño M, Lechner S, Rukavina A, Serrano I, Abele M, Koren A, Kubicek S, Knapp S, Gray NS, Superti-Furga G, Kuster B, Shi Y, Aloy P, Winter GE.   +29 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

A self-supervised machine learning pipeline for extracting information from live cell images at multiple doses and timepoints. [PDF]

Sci Rep
Isaev DY, Liu WP, Cuevas M, Tang Y, Ang K, Wilson C, Mai Q, Adra J, Cruz A, Nguyen K, Ricasa M, Gupta A, Hamadani M, Sridharan D, Yeghiazarians Y, Ameri K.   +15 more
europepmc   +1 more source

Plasticity within striatal direct pathway neurons after neonatal dopamine depletion is mediated through a novel functional coupling of serotonin 5‐HT₂ receptors to the ERK 1/2 map kinase pathway

, 2006
Pierre Brown, Charles R. Gerfen
openalex   +1 more source