Results 201 to 210 of about 274,417 (276)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The structural heterogeneity of AKT autoinhibition. [PDF]

Protein Sci
Xu L, Eren M, Weako J, Jang H, Keskin O, Gursoy A, Nussinov R.   +6 more
europepmc   +1 more source

An Efficient and Practical Method for the Synthesis of the 5-Acylamino-4-(4-pyrimidinyl)isoxazole Derivative AKP-001, a Potent P38 MAP Kinase Inhibitor

, 2017
Shuji Ohta, Takahisa Saito, Jun‐ya Kato, Shuichiro Sato, Hiroyuki Hayashi, Koichi Hasumi   +5 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Activity-based chemoproteomic profiling reveals the active kinome of <i>Leishmania</i>. [PDF]

Front Pharmacol
Porta EOJ, Kalesh K, Steel PG.
europepmc   +1 more source

Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase

, 2006
David Goldstein, Tom Alfredson, J. A. Bertrand, Michelle F. Browner, Ken Clifford, Stacie A. Dalrymple, James Dunn, José Freire-Moar, Seth F. Harris, Sharada S. Labadie, JoAnn La Fargue, Jean Marc Lapierre, Susan Larrabee, Fujun Li, Eva Papp, Daniel McWeeney, C S Ramesha, Rick Roberts, David S. Rotstein, Bong San Pablo, Eric B. Sjogren, On‐Yee So, Francisco X. Talamás, Will Tao, Alejandra Trejo, Armando G. Villaseñor, Mary Welch, Teresa D. Welch, Paul Weller, Phyllis E. Whiteley, Kelly A. Young, Sheila Zipfel   +31 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Formononetin ameliorates SP-induced urticaria in mice via suppressing TAK1/MAK signaling pathway. [PDF]

PLoS One
Wu Y, Li C.
europepmc   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

DyVarMap: Integrating Conformational Dynamics and Interpretable Machine Learning for Cancer-Associated Missense Variant Classification in FGFR2. [PDF]

Bioengineering (Basel)
Lian Y, Shehu A.
europepmc   +1 more source