Results 251 to 260 of about 274,417 (276)

Cyclin dependent kinase 5 (Cdk5) mediated inhibition of the MAP kinase pathway results in CREB down regulation and apoptosis in PC12 cells

Biochemical and Biophysical Research Communications, 2007
Cyclin dependent kinase 5 (cdk5) is active mainly in postmitotic cells like neurons and regulates important cellular functions by phosphorylating a wide variety of targets. Nerve growth factor stimulates the MEK-ERK MAP kinase pathway and causes neuronal differentiation and survival.
Monica, Sharma, Naresh Kumar, Hanchate, Rakesh K, Tyagi, Pushkar, Sharma   +3 more
openaire   +2 more sources

The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors

Behavioural Brain Research, 2012
p21-activated kinases (PAKs) are involved in signal cascades relevant for nociceptive processing and neuropathic pain. Particularly, the recently described group B PAKs 4, 5 and 6 regulate MAP-kinases and the rearrangement of the actin cytoskeleton, both of which have been linked to pain processing. However, a specific role of these PAKs in nociception
Ovidiu, Coste, Christine V, Möser, Marco, Sisignano, Katharina L, Kynast, Audrey, Minden, Gerd, Geisslinger, Ellen, Niederberger   +6 more
openaire   +2 more sources

MAP Kinase Phosphatase 5 Protects Against Sepsis-induced Acute Lung Injury (112.10)

The Journal of Immunology, 2012
Abstract Mitogen-activated protein kinases (MAPKs) play a critical role in inflammation. While activation of MAPK in inflammatory cells has been studied extensively, much less is known about the inactivation of these kinases. MAPK phosphatase 5 (MKP5) is a member of the dual specificity phosphatase family that dephosphorylates activated ...
Feng Qian, Jing Deng, Benjamin Gantner, Chen Dong, John Christman, Richard Ye   +5 more
openaire   +1 more source

MAP Kinase Phosphatase-5 Deficiency Impedes Arteriovenous Fistula Maturation

Physiology
Arteriovenous fistula (AVF), the gold standard for hemodialysis vascular access, is a vital lifeline for patients with renal failure. However, its low maturation rate remains a significant clinical challenge, incurring high economic costs and delaying treatment initiation.
Ruijia Feng, Rui Wang, Saamia Farooki, Dan Shan, Margaret Baldini, Roberto Vazquez-Padron, Jun Yu   +6 more
openaire   +1 more source

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

Science, 1993
Mitogen-activated protein (MAP) kinases p42 mapk and p44 mapk are activated in cells stimulated with epidermal growth factor (EGF) and other agents. A principal pathway for MAP kinase (MAPK) activation by EGF consists of sequential activations of the guanine nucleotide exchange factor Sos ...
J, Wu, P, Dent, T, Jelinek, A, Wolfman, M J, Weber, T W, Sturgill   +5 more
openaire   +2 more sources

2′,5′-Dihydroxychalcone down-regulates endothelial connexin43 gap junctions and affects MAP kinase activation

Toxicology, 2002
We examined the effect of 2',5'-dihydroxychalcone on connexin43 (Cx43) expression and gap-junctional communication in human umbilical vein endothelial cells (HUVEC). The result showed that expression of Cx43 is rapidly reduced by 2',5'-dihydroxychalcone in a dose-dependent manner, Concomitantly, the communication function, determined by fluorescence ...
Yi-Nan, Lee, Hung-I, Yeh, Tin-Yi, Tian, Wen-Wei, Lu, Yu-Shien, Ko, Cheng-Ho, Tsai   +5 more
openaire   +2 more sources

Differential signaling cascade of MAP kinase and S6 kinase depends on 3′,5′-monophosphate concentration in Schwann cells: correlation to cellular differentiation and proliferation

Brain Research, 1998
Schwann cells produce myelin in the peripheral nervous system (PNS) and play an important role in the maintenance of the normal function of PNS. Our previous studies have shown that derivatives of adenosine 3',5'-monophosphate (cAMP) can regulate the cell-fate (i.e., proliferation and differentiation into cell surface galactocerebroside-positive cells)
T, Mutoh, M, Li, M, Yamamoto, T, Mitsuma, G, Sobue   +4 more
openaire   +2 more sources

5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors

Life Sciences, 2004
In the present work, we tested the hypothesis that serotonin (5-hydroxytryptamine = 5-HT) might activate the extracellular signal-regulated kinase (ERK) pathway in human peripheral blood mononuclear cells (PBMC). PBMC were maintained in culture for 72 hrs at 37 degrees C prior to the addition of 5-HT. Our results showed an increase in ERK activation by
Isabelle, Cloëz-Tayarani, Usamah S, Kayyali, Barry L, Fanburg, Jean-Marc, Cavaillon   +3 more
openaire   +2 more sources

Mapping of the adenosine 5'-triphosphate binding site of type II calmodulin-dependent protein kinase

Biochemistry, 1987
The specificity of the ATP-binding site of the type II calmodulin-dependent protein kinase was probed with 25 analogues of ATP modified at various positions of the molecule. The analogues were compared by their ability to compete with ATP in the protein kinase reaction.
A P, Kwiatkowski, M M, King
openaire   +2 more sources

5-HT1A receptors mediate (+)8-OH-DPAT-stimulation of extracellular signal-regulated kinase (MAP kinase) in vivo in rat hypothalamus: Time dependence and regional differences

Brain Research, 2007
Brain serotonin 1A (5-HT1A) receptors play an important role in mood disorders and can modulate various intracellular signaling mechanisms. We previously reported that systemic administration of either full or partial 5-HT1A agonists increases neuroendocrine responses and that tandospirone, an azapirone partial agonist, can activate (phosphorylate ...
Crane, James W., Shimizua, Keiko, Carrascoa, Gonzalo A., Garciaa, Francisca, Jiab, Cuihong, Sullivana, Nicole R., D'Souzaa, Deborah N., Zhanga, Yahong, Van de Kara, Louis D., Mumaa, Nancy A., Battaglia, George   +10 more
openaire   +3 more sources