Results 21 to 30 of about 274,417 (276)

Xaliproden (SR57746A) Induces 5-Ht1A Receptors-Mediated Map Kinase Activation in Pc12 Cells [PDF]

International Journal of Immunopathology and Pharmacology, 2005
Neurotrophic growth factors are involved in cell survival. However, natural growth factors have a very limited therapeutic use because of their short half-life. In the present study, we investigated the mechanism of action of a non peptidic neurotrophic drug, Xaliproden, a potential molecule for the treatment of motoneuron diseases, since the ...
Appert-Collin, A., Duong, F.H.T., Passilly Degrace, P., Bennasroune, A., Poindron, P., Warter, J.M., Gies, J.P.   +6 more
openaire   +3 more sources

Contribution of Ras farnesyl transferase, MAP kinase and cytochrome P-450 metabolites to endothelin-1 induced hypertension

Biomolecules & Biomedicine, 2011
Endothelin 1 (ET-1) is vasoactive peptide that acts via ET-A receptors coupling inducing vascular smooth muscle cell proliferation and contraction. ET-1 is involved in the development and maintenance of hypertension.
Farid Ljuca, Gorazd Drevenšek, Enver Zerem   +2 more
doaj   +1 more source

Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-β-activated kinase 1

OncoImmunology, 2022
DNA damage by genotoxic drugs such as gemcitabine and 5-fluorouracil (5-FU) activates the ataxia telangiectasia, mutated (ATM)-Chk pathway and induces the expression of NKG2D ligands such as the MHC class I-related chain A and B (MICA/B).
Jingxiang Wang, Kai Liu, Tianxiang Xiao, Penggang Liu, Richard A. Prinz, Xiulong Xu   +5 more
doaj   +1 more source

The Role of Big Mitogen-Activated Protein Kinase 1 (BMK1) / Extracellular Signal-Regulated Kinase 5 (ERK5) in the Pathogenesis and Progression of Atherosclerosis

Journal of Pharmacological Sciences, 2012
Big mitogen-activated protein kinase 1 (BMK1), also known as extracellular signal-regulated kinase 5 (ERK5), is a newly identified member of the mitogen-activated protein (MAP) kinase family.
Masanori Yoshizumi, Yoji Kyotani, Jing Zhao, Kosuke Nagayama, Satoyasu Ito, Yuichi Tsuji, Kentaro Ozawa   +6 more
doaj   +1 more source

Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting

Journal of Lipid Research, 1999
Phosphomevalonate kinase catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate and was originally believed to be a cytosolic enzyme. In this study we have localized the phosphomevalonate kinase gene to chromosome 1p13–1q22–23 and
Lisa M. Olivier, Ken L. Chambliss, K. Michael Gibson, Skaidrite K. Krisans   +3 more
doaj   +1 more source

Molecular subtyping of cancer and nomination of kinase candidates for inhibition with phosphoproteomics: Reanalysis of CPTAC ovarian cancerResearch in context

EBioMedicine, 2019
Background: Molecular subtyping of cancer aimed to predict patient overall survival (OS) and nominate drug targets for patient treatments is central to precision oncology.
Mengsha Tong, Chunyu Yu, Dongdong Zhan, Ming Zhang, Bei Zhen, Weimin Zhu, Yi Wang, Congying Wu, Fuchu He, Jun Qin, Tingting Li   +10 more
doaj   +1 more source

ARTEMIN Promotes Oncogenicity and Resistance to 5-Fluorouracil in Colorectal Carcinoma by p44/42 MAPK Dependent Expression of CDH2

Frontiers in Oncology, 2021
ARTEMIN (ARTN), one of the glial-cell derived neurotrophic factor family of ligands, has been reported to be associated with a number of human malignancies.
Qiu-Shi Zhuang, Qiu-Shi Zhuang, Qiu-Shi Zhuang, Xin-Bao Sun, Xin-Bao Sun, Qing-Yun Chong, Arindam Banerjee, Arindam Banerjee, Min Zhang, Min Zhang, Zheng-Sheng Wu, Tao Zhu, Tao Zhu, Vijay Pandey, Vijay Pandey, Peter E. Lobie, Peter E. Lobie, Peter E. Lobie, Peter E. Lobie   +18 more
doaj   +1 more source

Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons

Molecular Pain, 2007
Background Although substance P (SP) is an important primary afferent modulator in nociceptive processes, it is unclear whether SP regulates its own release from primary sensory neurons.
Arihiro Koji, Li Yu-Sang, Tang He-Bin, Nakata Yoshihiro   +3 more
doaj   +1 more source

ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity. [PDF]

PLoS ONE, 2014
Cyclin-dependent kinase 5 is a proline-directed serine/threonine kinase and its activity participates in the regulation of nociceptive signaling. Like binding with the activators (P35 or P25), the phosphorylation of Cdk5 plays a critical role in Cdk5 ...
Xiaoqin Zhang, Honghai Zhang, Haijun Shao, Qingsheng Xue, Buwei Yu   +4 more
doaj   +1 more source

Mechanical Stretch Induced Osteogenesis on Human Annulus Fibrosus Cells through Upregulation of BMP-2/6 Heterodimer and Activation of P38 and SMAD1/5/8 Signaling Pathways

Cells, 2022
Degenerative disc disease (DDD) is an important cause of low back pain. Repetitive tensile stress from the daily motion of the spine predisposes it to injury of the annulus fibrosus (AF) which causes IVD degeneration.
Cheng-Nan Chen, Hsin-I Chang, Chia-Kung Yen, Wen-Lung Liu, Kuo-Yuan Huang   +4 more
doaj   +1 more source