Results 31 to 40 of about 274,417 (276)

The genetic landscape of ganglioglioma

Acta Neuropathologica Communications, 2018
Ganglioglioma is the most common epilepsy-associated neoplasm that accounts for approximately 2% of all primary brain tumors. While a subset of gangliogliomas are known to harbor the activating p.V600E mutation in the BRAF oncogene, the genetic ...
Melike Pekmezci, Javier E. Villanueva-Meyer, Benjamin Goode, Jessica Van Ziffle, Courtney Onodera, James P. Grenert, Boris C. Bastian, Gabriel Chamyan, Ossama M. Maher, Ziad Khatib, Bette K. Kleinschmidt-DeMasters, David Samuel, Sabine Mueller, Anuradha Banerjee, Jennifer L. Clarke, Tabitha Cooney, Joseph Torkildson, Nalin Gupta, Philip Theodosopoulos, Edward F. Chang, Mitchel Berger, Andrew W. Bollen, Arie Perry, Tarik Tihan, David A. Solomon   +24 more
doaj   +1 more source

Ral Signals through a MAP4 Kinase-p38 MAP Kinase Cascade in C. elegans Cell Fate Patterning

Cell Reports, 2018
Summary: C. elegans vulval precursor cell (VPC) fates are patterned by an epidermal growth factor (EGF) gradient. High-dose EGF induces 1° VPC fate, and lower dose EGF contributes to 2° fate in support of LIN-12/Notch. We previously showed that the EGF 2°
Hanna Shin, Rebecca E.W. Kaplan, Tam Duong, Razan Fakieh, David J. Reiner   +4 more
doaj   +1 more source

From 2-Alkylsulfanylimidazoles to 2-Alkylimidazoles: An Approach towards Metabolically More Stable p38α MAP Kinase Inhibitors

Molecules, 2017
In vitro and in vivo metabolism studies revealed that 2-alkylsulfanylimidazole ML3403 (4-(5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl)-N-(1-phenylethyl)pyridin-2-amine) undergoes rapid oxidation to the sulfoxide.
Fabian Heider, Urs Haun, Eva Döring, Mark Kudolo, Catharina Sessler, Wolfgang Albrecht, Stefan Laufer, Pierre Koch   +7 more
doaj   +1 more source

The Hallucinogenic Serotonin2A Receptor Agonist, 2,5-Dimethoxy-4-Iodoamphetamine, Promotes cAMP Response Element Binding Protein-Dependent Gene Expression of Specific Plasticity-Associated Genes in the Rodent Neocortex

Frontiers in Molecular Neuroscience, 2021
Psychedelic compounds that target the 5-HT2A receptor are reported to evoke psychoplastogenic effects, including enhanced dendritic arborization and synaptogenesis.
Lynette A. Desouza, Madhurima Benekareddy, Sashaina E. Fanibunda, Sashaina E. Fanibunda, Farhan Mohammad, Balaganesh Janakiraman, Utkarsha Ghai, Tamar Gur, Julie A. Blendy, Vidita A. Vaidya   +9 more
doaj   +1 more source

Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways

Respiratory Research, 2009
Background Synthetic peptides containing the RGD sequence inhibit integrin-related functions in different cell systems. Here, we investigated the effects of synthetic Arg-Gly-Asp-Ser (RGDS) peptide on key inflammatory responses to intratracheal (i.t ...
Hah Jong, Park Hyun-Jung, Han Jeong, Moon Changsuk, Kang Jihee   +4 more
doaj   +1 more source

Loss of MKP-5 promotes myofiber survival by activating STAT3/Bcl-2 signaling during regenerative myogenesis

Skeletal Muscle, 2017
Background The mitogen-activated protein kinases (MAPKs) have been shown to be involved in regulating myofiber survival. In skeletal muscle, p38 MAPK and JNK are negatively regulated by MAPK phosphatase-5 (MKP-5).
Kisuk Min, Ahmed Lawan, Anton M. Bennett
doaj   +1 more source

Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells [PDF]

Diabetes & Metabolism Journal, 2015
BackgroundMetformin, a well-known anti-diabetic drug, has gained interest due to its association with the reduction of the prevalence of cancer in patients with type 2 diabetes and the anti-proliferative effect of metformin in several cancer cells. Here,
Deok-Bae Park
doaj   +1 more source

Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes

Journal of Biomedical Science, 2011
Background Osteoarthritis (OA) is characterized by the degradation of articular cartilage, marked by the breakdown of matrix proteins. Studies demonstrated the involvement of chemokines in this process, and some may potentially serve as diagnostic ...
Chao Pin-Zhir, Hsieh Ming-Shium, Cheng Chao-Wen, Lin Yung-Feng, Chen Chien-Ho   +4 more
doaj   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source