Results 101 to 110 of about 1,358,257 (368)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans [PDF]

, 2019
Although the association between high blood pressure (BP), particularly in midlife, and late-life dementia is known, less is known about variations by race and sex.
Cushman, Mary, Galecki, Andrzej T., Giordani, Bruno, Kabeto, Mohammed U., Langa, Kenneth M., Levine, Deborah A., McClure, Leslie A., Safford, Monika M., Unverzagt, Frederick W., Wadley, Virginia G.   +9 more
core   +1 more source

Association between menopausal hormone therapy, mammographic density and breast cancer risk: results from the E3N cohort study

Breast Cancer Research, 2021
Background Menopausal hormone therapy (MHT) is a risk factor for breast cancer (BC). Evidence suggests that its effect on BC risk could be partly mediated by mammographic density.
M. Fornili, V. Perduca, A. Fournier, A. Jérolon, M. C. Boutron-Ruault, G. Maskarinec, G. Severi, L. Baglietto   +7 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Barriers and facilitators to safer supply pilot program implementation in Canada: a qualitative assessment of service provider perspectives

Harm Reduction Journal
Background In response to the ongoing drug toxicity crisis, driven by fentanyl and its analogues in the unregulated drug supply, Canada has funded several safer supply programs, which provide pharmaceutical-grade medications to reduce the reliance on ...
Frishta Nafeh, Lucas Martignetti, Carol Strike, Gillian Kolla, Matthew Bonn, Caroline Brunelle, Jade Boyd, Elaine Hyshka, Cassidy Morris, Jolene Eeuwes, Heather Hobbs, Elizabeth Haywood, Bernadette Pauly, Dan Werb, Mohammad Karamouzian   +14 more
doaj   +1 more source

An Evidence Map of the Women Veterans’ Health Research Literature (2008–2015)

Journal of general internal medicine, 2017
BackgroundWomen comprise a growing proportion of Veterans seeking care at Veterans Affairs (VA) healthcare facilities. VA initiatives have accelerated changes in services for female Veterans, yet the corresponding literature has not been systematically ...
Elisheva R. Danan, E. Krebs, K. Ensrud, Eva Koeller, R. MacDonald, T. Velasquez, N. Greer, T. Wilt   +7 more
semanticscholar   +1 more source

Mapping uncertainty in precision medicine: A systematic scoping review

Journal of Evaluation in Clinical Practice, 2022
AbstractRationaleAlthough precision medicine is seen by many as one of the most promising advances in the field of medicine, it has also raised critical questions at various levels. Many of these concerns revolve around an observation described by Kimmelman and Tannock as the ‘paradox of precision medicine’: somewhat surprisingly, uncertainty seems to ...
openaire   +4 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

A genetic linkage map of the fungus Phycomyces blakesleeanus [PDF]

, 2010
Comparative Medicine - OneHealth and Comparative Medicine Poster SessionPhycomyces blakesleeanus is a filamentous fungus of research interest because of its ability to sense and respond to its environment.
Chaudhary, Suman, Idnurm, Alexander
core  

Human monkeypox: a comparison of the characteristics of the new epidemic to the endemic disease

BMC Infectious Diseases, 2022
In May 2022, a new global outbreak of mpox (formerly, human monkeypox) emerged that was declared a public health emergency of international concern by the World Health Organization on July 23, 2022.
Sharon Sukhdeo, Sharmistha Mishra, Sharon Walmsley   +2 more
doaj   +1 more source