Results 201 to 210 of about 1,443,694 (284)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The effect of intravenous calcium administration on haemodynamics in perioperative cardiothoracic surgery and intensive care: A narrative review. [PDF]

Crit Care Resusc
Miller A, Omassoli J, Simpson J, Brooks K, Almeida A, Ling RR, Subramaniam A.   +6 more
europepmc   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Awake Flexible Scope Intubation in Critically Ill Patients With Physiologically Difficult Airways: A Prospective, Observational Case Series. [PDF]

Crit Care Explor
Camiré DCD, Ramaswamy TS, Chu LF, Mihm FG.   +3 more
europepmc   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Knowledge mapping of macrophage in AKI: A bibliometric analysis. [PDF]

Medicine (Baltimore)
Gao J, Tan RZ, Zhao WJ, Su HW, Wang L, Liu J.   +5 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Intraoperative Hypotension and Vasoactive Treatment: An International Survey of Anaesthesiologists. [PDF]

Acta Anaesthesiol Scand
Bækgaard ES, Vester-Andersen M, Crone V, Møller MH, Yamanaka S, Palmarsdottir R, Uusalo P, Haidl F, Rådestad M, van der Sloot K, Corona A, Johnström A, Nørskov AK, Karlsen APH, Faustad BI, Sørensen CB, Spies F, Krogh HB, El-Hallak H, Mistry JM, Mønnich JK, Olesen KG, Madsen KPD, Voogd KL, Reich LM, Kolstrup LA, Juhl-Olsen P, Körner LK, Sigurdsson MI, Jensen-Holm MB, Slavensky JA, Toft MH, Jørgensen ML, Andersen M, Jensen MSH, Saei M, Hedetoft M, Hansen PM, Hansen RT, Lundsgaard RS, Krarup SMI, Wiberg S, Laustrup T, Brizzi G, Kreutziger J, Onyemuchara I, Adeniji A, Colville T, Keitley JA, Khan M, Millar M, Lennie I, Kelly K, Brooker V, Roberts J, Lipton G, Keohone J, Chebbout R, Bond O, Milligan W, O'Brien C, Wright E, Linton F, Towell C, Shuttleworth J, Norton J, Butler D, Frankland S, Screech F, Charig L, Walsh S, Davies R, Jones E, Dalmonte E, Evans M, Krag M.   +75 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source