Results 171 to 180 of about 2,848,636 (250)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Invasion Patterns and Niche Dynamics of the Pollinivorous Florida Calligrapher, <i>Toxomerus floralis</i> (Diptera: Syrphidae) in the Afrotropical Region. [PDF]

Ecol Evol
Muller B, Midgley J, Goergen G, Al Jahdhami A, Azo'o Ela M, Bellingan T, Cavaillès S, Copeland R, De Meyer M, Hauser M, Holmes A, Mengual X, Nève G, Reemer M, Skevington J, Ståhls G, Sinzinkayo E, Smit J, Ssymank A, Theron G, Jordaens K.   +20 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

High-resolution climate-dengue modeling and mid-century projections under SSP5-8.5 in Costa Rica. [PDF]

Sci One Health
Hidalgo HG, Alfaro EJ, Sanchez F, Troyo A, Maldonado T, Miranda-Chacón Z, Morales-Mora E, Solano-Gamboa M, Acosta-Quesada M.   +8 more
europepmc   +1 more source

Map Projections@@@A Sketch of the Subject of Map Projections

C. F. Close
semanticscholar   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Jointly-hic: joint decomposition of contact frequency maps captures salient features of genome architecture across tissues and development. [PDF]

Genome Biol
Reimonn T, Yilmaz VO, Tran H, Ng G, Liu D, Abdennur N.   +5 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Impact of ambient fine particulate matter (PM_2.5) pollution on disease burden in BRICS from 1990 to 2023: evidence from the Global Burden of Disease Study 2023. [PDF]

BMJ Glob Health
Si S, Deng S, Zhang Y, Wang X, Yue G, Sun Y, Lu H, Li J, Tao F, Lin M, Dong Z, Zhuo B, Li L, Pang B, Jin X, Meng Z, Shi J.   +16 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source