Results 181 to 190 of about 2,506,502 (302)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Global lung cancer burden, trends, and projections from 2010 to 2050: A population-level severity framework integrating DALYs-per-case and mortality-to-incidence ratio. [PDF]

PLoS One
Freihat O, Aamir M, Cselik Z, Kovacs A, Sipos D.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Multi-modal direct LINAC parameter prediction for pancreatic VMAT: An optimization-free approach. [PDF]

Med Phys
Guan Z, Shimizu Y, Iwai T, Yoshimura M, Mizowaki T, Nakamura M.   +5 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Map of the city of Melbourne [cartographic material] : including the municipalities of Emerald Hill & Collingwood ... /

Map 282 from Ferguson Collection.; Map shows streets, railways, buildings, parks and reserves, and names wards.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.map-f282; Library copy folded to 16.8 x 11.5 ...
Mason, Cyrus, 1830-1915.
core  

Post-establishment environmental suitability of <i>Aedes aegypti</i> and <i>Aedes albopictus</i> in Iran under SSP-based climate scenarios. [PDF]

One Health
Bozorg-Omid F, Rahimi M, Kafash A, Foroushani AR, Akhavan AA, Snow RW, Muchiri SK, Ostadtaghizadeh A, Hanafi-Bojd AA.   +8 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Multiscale assessment of transboundary water-food-energy nexus under climate change in Irtysh River Basin. [PDF]

iScience
Wang X, Wang X, Jin H, Liu H, Li Y.
europepmc   +1 more source