Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits [PDF]
arXiv, 2023 Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented.
arxiv
Depletion of Branched-Chain Aminotransferase 2 (BCAT2) Enzyme Impairs Myoblast 3 Survival and Myotube Formation [PDF]
, 2019 Much is known about the positive effects of branched-chain amino acids (BCAA) in regulating muscle protein metabolism. Comparatively much less is known about the effects of these amino acids and their metabolites in regulating myotube formation.
ADEGOKE, OLASUNKANMI +2 more
core
Confluent Thalamic Hyperintensities in CADASIL [PDF]
, 2010 Background: CADASIL is responsible for diffuse hyperintensities in the white matter on FLAIR images. These lesions are often associated with focal lesions in the basal ganglia such as lacunar infarctions.
Chabriat, Hugues +6 more
core +1 more source
Maple syrup urine disease presenting as severe neonatal metabolic encephalopathy: a case report
, 2020 A study done by Dindagur N et al, found that among 3550 symptomatic Indian children, 113 cases (3.2%) were identified with a metabolic disorder.
R. Patil +4 more
semanticscholar +1 more source
An engineered gastrointestinally stable microbial leucine decarboxylase for potential treatment of maple syrup urine disease [PDF]
, 2023 Please click Additional Files below to see the full ...
Alaoui Ismaili, Moulay Hicham +20 more
core +1 more source
Maple Syrup Urine Disease [PDF]
Proceedings of the Royal Society of Medicine, 1968 G. W. Hatcher, C E Dent
openaire +6 more sources
Expression of mitochondrial branched-chain aminotransferase and α-keto-acid dehydrogenase in rat brain: implications for neurotransmitter metabolism [PDF]
, 2012 In the brain, metabolism of the essential branched chain amino acids (BCAAs) leucine, isoleucine, and valine, is regulated in part by protein synthesis requirements. Excess BCAAs are catabolized or excreted. The first step in BCAA catabolism is catalyzed
Cole, Jeffrey T. +2 more
core +2 more sources
Skin Lesions Associated with Nutritional Management of Maple Syrup Urine Disease
Case Reports in Dermatological Medicine, 2017 Introduction. Maple syrup urine disease (MSUD) is an inborn error of branched chain amino acids (BCAAs) metabolism. We report an infant with MSUD who developed 2 episodes of cutaneous lesions as a result of isoleucine deficiency and zinc deficiency ...
Jaraspong Uaariyapanichkul +4 more
doaj +1 more source
Food for thought : palatable eponyms from Pediatrics [PDF]
, 2014 Food-related medical terms are frequently used in the field of pediatrics for the definition, recognition and diagnosis of disease. Almost 40 food-related medical eponyms used in Pediatrics have been ‘cherry picked’ and described by the authors.
Kipersztok, Lisa, Masukume, Gwinyai
core
Inborn errors of metabolism: a clinical overview [PDF]
, 1999 CONTEXT: Inborn errors of metabolism cause hereditary metabolic diseases (HMD) and classically they result from the lack of activity of one or more specific enzymes or defects in the transportation of proteins.
Martins, Ana Maria
core +4 more sources