Results 151 to 160 of about 4,970,383 (343)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Mapping of reinforcing and analgesic effects of the mu opioid agonist Endomorphin-1 in the ventral midbrain of the rat

, 2012
Thomas C. Jhou, Shengping Xu, Mary R. Lee, Courtney L. Gallen, Satoshi Ikemoto   +4 more
openalex   +2 more sources

Mapping Structural Determinants within Third Intracellular Loop That Direct Signaling Specificity of Type 1 Corticotropin-releasing Hormone Receptor [PDF]

, 2012
Anu Punn, Jing Chen, Maria Delidaki, Jiyou Tang, George Liapakis, Hendrik Lehnert, Michael A. Levine, Dimitris Grammatopoulos   +7 more
openalex   +1 more source

Feasibility of mapping and ablating ectopy-triggering ganglionated plexus reproducibly in persistent atrial fibrillation [PDF]

, 2023
Clare Coyle, Simos Koutsoftidis, Min-Young Kim, Bradley Porter, Daniel Keene, Vishal Luther, Balvinder Handa, Jamie Kay, Elaine Lim, Louisa Malcolme‐Lawes, Michael Koa‐Wing, Phang Boon Lim, Zachary I. Whinnett, Fu Siong Ng, Norman Qureshi, Nicholas S. Peters, Nick Linton, Emmanuel M. Drakakis, Prapa Kanagaratnam   +18 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

HARMONIC MAPPINGS [PDF]

Proceedings of the National Academy of Sciences, 1954
openaire   +3 more sources

Rapid and Precise Retinotopic Mapping of the Visual Cortex Obtained by Voltage-Sensitive Dye Imaging in the Behaving Monkey

, 2007
Zhiyong Yang, David J. Heeger, Eyal Seidemann   +2 more
openalex   +1 more source

KNN-MDR: a learning approach for improving interactions mapping performances in genome wide association studies [PDF]

, 2017
Sinan Abo Alchamlat, Frédéric Farnir
openalex   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source