Results 251 to 260 of about 7,191,228 (334)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Two-Minute Deep Learning-Powered Brain Quantitative Mapping: Accelerating Clinical Imaging With Synthetic Magnetic Resonance Imaging.

JMIR Med Inform
Liu Y, Yin H, Zheng Z, Liu W, Zhang T, Cai L, Niu H, Lv H, Yang Z, Wang Z, Ren P.   +10 more
europepmc   +1 more source

Recent advances in single-cell bioinformatics for inferring higher-order chromatin contact maps. [PDF]

BMB Rep
Noh SK, Lee M, Jeong H.
europepmc   +1 more source

Crowdsourced biodiversity monitoring fills gaps in global plant trait mapping. [PDF]

Nat Commun
Lusk D, Wolf S, Svidzinska D, Dormann CF, Kattge J, Bruelheide H, Sabatini FM, Damasceno G, Moreno Martínez Á, Violle C, Hending D, Hähn GJA, Tabeni S, Phartyal S, Gonçalves F, Kreft H, Schmidt M, Chen H, Güler B, Dolezal J, Pielech R, Guido A, Dwyer C, Napoleone F, Willie J, Gasper AL, Macía MJ, Chytry M, Lenoir J, Thakur D, Dengler J, Świerszcz S, Altman J, Mucina L, Nerlekar AN, Kakinuma K, Rawat P, Stančić Z, Testolin R, Hatim MZ, Rodrigues F, Homeier J, Marques MCM, McCarthy JK, El-Sheikh MA, Korznikov K, Gerberding K, Kattenborn T.   +47 more
europepmc   +1 more source

Mobile Health Application for the Prevention of Stroke (MAPS): a pilot, single-arm study on an innovative health application designed for primary stroke prevention. [PDF]

BMC Neurol
Ungerer MN, Reichel K, Feisst M, Tunkl C, Quenzer B, Gumbinger C.   +5 more
europepmc   +1 more source

Computed tomography perfusion-defined ischemic core predicts functional outcome after basilar artery thrombectomy. [PDF]

Front Neurol
Chen P, Li X, Huang Y, Hui J, Rao J, Zhang W, Shang L, Chen X, Gao R, Zhou J, Ding Q, Xia S, Ji J.   +12 more
europepmc   +1 more source

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain. [PDF]

Brain Struct Funct
Hansen JY, Tuisku J, Johansson J, Chang Z, McGinnity CJ, Beliveau V, Guimond S, Ganz M, Nørgaard M, Galovic M, Bezgin G, Cox SML, Hietala J, Leyton M, Kobayashi E, Rosa-Neto P, Funck T, Palomero-Gallagher N, Knudsen GM, Marsden P, Hammers A, Nummenmaa L, Tuominen L, Misic B.   +23 more
europepmc   +1 more source