Results 41 to 50 of about 562,350 (159)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Consideraciones sobre la Realeza de Nuestra Señora

Estudios Eclesiásticos, 1956
El presente estudio aborda lo relativo a la Realeza de María. Algunas explicaciones parten de su maternidad para justificar su papel de Reina. Se analizan los conceptos de rey y reina para acercarse a la comprensión de María, así como la analogía con su ...
José Antonio de Aldama
doaj  

TRACTOGRAFÍA Y TENSOR DE DIFUSIÓN EN EL ESTUDIO POR RESONANCIA MAGNÉTICA DEL NERVIO MEDIANO: REPORTE DE UN CASO

Revista Chilena de Radiología
Introducción: La resonancia magnética es una herramienta indispensable en el estudio de enfermedades del sistema nervioso central. Varios estudios consideran la aplicación del tensor de difusión (DTI) y tractograf ía en el estudio de nervios periféricos.
Paulina Yañez S, Yessenia Orellana A, Daniela Vega T, Marco Naranjo R, Fernando Navarro H   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

María en la Biblia y el signo de la Visitación

Estudios Eclesiásticos, 1970
La presente nota gira en torno a las obras marianas escritas por Ortensio da Spinetoli y la posterior respuesta en forma de libro de Alessio Martinelli.
Sebastián Bartina
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

¿Vale el testimonio de san Efrén en favor de la Inmaculada?

Estudios Eclesiásticos, 1954
Algunos años después de la definición del dogma de la Inmaculada, G. Bickell publicó los “Carmina Nisibena” de san Efrén. Eran unos cánticos cuya autenticidad se apoyaba en la edad de los códices siríacos que los contienen.
Ignacio Ortiz de Urbina
doaj  

Taxonomic, physicochemical, phenolic and antioxidant comparison in species of high Andean wild fruits: Rubus and Hesperomeles

Acta Agronómica
Currently, humans are taking better care of their health. It is known that fruit consumption prevents degenerative diseases such as cancer and diabetes.
Carlos Alberto Ligarda-Samanez, David Choque-Quispe, Betsy S. Ramos-Pacheco, Abelardo Yanahuillca-Vargas, Mary L. Huamán-Carrión, Elibet Moscoso-Moscoso, Henry Palomino-Rincón   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source