Results 51 to 60 of about 562,350 (159)

Madre del hombre libre

Estudios Eclesiásticos, 1976
El presente estudio elabora una reflexión teológica acerca de cómo es María madre del hombre libre. Se considera que tanto el protestantismo como el catolicismo le deben mucho a las interpretaciones de la fe cristiana y la acción de Dios en la historia ...
Adolfo González Montes
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Entrevista con Charles Portilla Revollar

Revista de Psicología, 2020
Charles Portilla ...
Ronald Delgado Morales, Bianca López Bobbio, Luisa Mazeyra Zúñiga, Lizbeth Medina Zeballos, Sol Ojeda Cama, Rodrigo Quispe Gutiérrez, Rosmery Taya Huamaní   +6 more
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Culturable diversity and antimicrobial activity of Actinobacteria from marine sediments in Valparaíso bay, Chile

Frontiers in Microbiology, 2015
Marine-derived Actinobacteria are a source of a broad variety of secondary metabolites with diverse biological activities, such as antibiotics and antitumorals; many of which have been developed for clinical use. Rare Actinobacteria represent an untapped
Fernanda Paz Claverías, Agustina Natalia Undabarrena, Myriam eGonzález, Michael eSeeger, Beatriz Patricia Cámara   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Caracterización de desórdenes músculo esqueléticos más frecuentes de origen laboral en Colombia

Signos
El objetivo del presente artículo es caracterizar los Desórdenes Musculoesqueléticos (DME) más frecuentes de origen laboral, los cuales pueden afectar estructuras corporales del sistema musculoesquelético en Colombia, en un periodo entre el año 2011 y ...
Gladys Tamayo Perdomo, Carmen Lorena Murillo Panameño, María Carolina Cerón Polanco, Maira Alejandra Camargo Valderrama, Angie Thalía Murcia Agudelo   +4 more
doaj   +1 more source

Muro de contención construido con neumáticos estabilizados mecánicamente

Revista Ingeniería de Construcción, 2019
En el último gran incendio que afectó a Valparáso el año 2014 quedaron al descubierto muchas deficiencias, tanto estructurales como constructivas, sobre la edificación en pendiente, factores que fueron determinantes en la cantidad de viviendas ...
Francisco Valdés, P. Barros, G. Sarabia, P. Serrano, I. Gaytan   +4 more
doaj   +1 more source