Results 111 to 120 of about 294 (212)
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, EarlyView.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
Brain Pathology, EarlyView.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire +28 more
wiley +1 more source
Simulación numérica de la distribución de nódulos de manganeso en el fondo del mar
, 1991 En este trabajo se realiza un desarrollo de cálculo numérico aplicable a la detección de objetos en el fondo sedimentario, el interés del mismo se centra en los yacimientos de nódulos de manganeso. Se emplea el método de simulación numérica que distribuye aleatoriamente áreas representativas en un plano, empleando para ello las distribuciones ...
openaire +1 more source
Ingeniería e Investigación, 2008 El presente artículo sintetiza los principios de la altimetría radar por satélite y presenta las aplicaciones más relevantes que dicha tecnología ha aportado al estudio de aguas superficiales continentales bajo un dominio que se comienza a conocer como ...
Juan Gabriel León Hernández +2 more
doaj
Clinical &Experimental Allergy, EarlyView.Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun +13 more
wiley +1 more source
Clinical &Experimental Allergy, EarlyView.Mapping IgG epitopes of the major birch allergen Bet v 1 identified patient‐derived, hypoallergenic peptides that did not trigger degranulation. These findings support a novel, safer approach for peptide‐based allergen immunotherapy that leverages naturally induced IgG specificities from allergic individuals. ABSTRACT Background Allergen immunotherapy (
Lara Šošić +10 more
wiley +1 more source
A review of the literature on the environmental impacts of marine fish cage culture.
Uniciencia, 1998 Se presenta una revisión compresiva de la literatura relacionada con los impactos ambientales producidos por el cultivo de peces marinos en jaulas. Es poca la investigación que se ha realizado sobre este tipo de impacto en ambientes tropicales, por lo ...
Jennifer Watts, Douglas E. Conklin
doaj
Differential Effects of Benralizumab and Mepolizumab on Pro‐Resolving Mediators
Allergy, EarlyView.
Jaime Bernaola +14 more
wiley +1 more source
Terrain Synthesis and Authoring based on Iso‐Contours
Computer Graphics Forum, EarlyView.Abstract Digital terrains are central to realistic landscape depiction, yet authoring tools must balance perceptual realism with intuitive artistic control. We propose a compact vector‐based representation that models terrain as nested iso‐contours, inspired by geomorphology and cartography.
B. Huftier +5 more
wiley +1 more source