Results 11 to 20 of about 178,432 (330)

Cheminformatics Strategies Unlock Marburg Virus VP35 Inhibitors from Natural Compound Library

Viruses, 2023
The Ebola virus and its close relative, the Marburg virus, both belong to the family Filoviridae and are highly hazardous and contagious viruses. With a mortality rate ranging from 23% to 90%, depending on the specific outbreak, the development of ...
Isra M. Alsaady, Leena H. Bajrai, Thamir A. Alandijany, Hattan S. Gattan, Mai M. El-Daly, Sarah A. Altwaim, Rahaf T. Alqawas, Vivek Dhar Dwivedi, Esam I. Azhar   +8 more
doaj   +2 more sources

Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa. [PDF]

Nature Communications, 2020
Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus ...
Amara, Emmanuel, Amman, Brian R, Bairoh, Fatmata V, Bakarr, Ibrahim A, Bangura, Abdulai A, Bangura, Camilla, Bangura, Doris, Bangura, James, Belaganahalli, Manjunatha, Bird, Brian H, Chow, Andrew, Conteh, Immah, Coomber, Moinya, Dhanota, Jasjeet, Edwin, Lavalie, Foday, Ibrahim, Gbakima, Aiah A, Gibson, Alexandra, Goldstein, Tracey, Graziano, James, Guetiya Wadoum, Raoul Emeric, Jambai, Amara, Johnny, Jonathan, Kamanda, Emmanuel S, Kamara, Sorie M, Kanu, Marilyn, Kanu, Osman, Kargbo, Dickson, Koroma, Alusine H, Lebbie, Aiah, Lungai, Victor, Mazet, Jonna AK, Mereweather-Thompson, Vanessa, Musa, Jonathan, Nichol, Stuart T, Ontiveros, Victoria, Osborne, Augustus, Patel, Ketan, Robert, Willie, Saidu, Emmanuel, Schuh, Amy J, Sealy, Tara K, Singh, Tushar, Taboy, Celine H, Towner, Jonathan S, Tremeau-Bravard, Alexandre, Turay, Joseph, Turay, Mohamed, Wadsworth, Richard, Williams, Samuel Maxwell Tom   +49 more
core   +2 more sources

Marburg virus disease: A summary for clinicians

International Journal of Infectious Diseases, 2020
Objectives: This article summarizes the countermeasures for Marburg virus disease, focusing on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and vaccines that have demonstrated, through their evaluation in nonhuman ...
Mark G. Kortepeter, Kerry Dierberg, Erica S. Shenoy, Theodore J. Cieslak   +3 more
doaj   +2 more sources

Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

Nature Communications, 2023
Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In
Vanessa Monteil, Hyesoo Kwon, Lijo John, Cristiano Salata, Gustav Jonsson, Sabine U. Vorrink, Sofia Appelberg, Sonia Youhanna, Matheus Dyczynski, Alexandra Leopoldi, Nicole Leeb, Jennifer Volz, Astrid Hagelkruys, Max J. Kellner, Stéphanie Devignot, Georg Michlits, Michelle Foong-Sobis, Friedemann Weber, Volker M. Lauschke, Moritz Horn, Heinz Feldmann, Ulrich Elling, Josef M. Penninger, Ali Mirazimi   +23 more
doaj   +2 more sources

The Current Pathogenicity and Potential Risk Evaluation of Marburg Virus to Cause Mysterious “Disease X”—An Update on Recent Evidences

Environmental Health Insights
The World Health Organization (WHO) defined Disease X as an upcoming disease with the potential to cause a pandemic. Pathogen X is responsible for Disease X.
Rahima Akter Mitu, Md. Rabiul Islam
doaj   +2 more sources

Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges

Frontiers in Microbiology, 2023
The Marburg virus (MV), identified in 1967, has caused deadly outbreaks worldwide, the mortality rate of Marburg virus disease (MVD) varies depending on the outbreak and virus strain, but the average case fatality rate is around 50%.
Shriyansh Srivastava, Deepika Sharma, S Kumar, Aditya Sharma, Rishikesh Rijal, Ankush Asija, Suraj Adhikari, S. Rustagi, S. Sah, Z. H. Al-qaim, Prashant Bashyal, A. Mohanty, J. J. Barboza, A. Rodríguez-Morales, Ranjit Sah   +14 more
semanticscholar   +1 more source

Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial.

The Lancet, 2023
BACKGROUND WHO has identified Marburg virus as an emerging virus requiring urgent vaccine research and development, particularly due to its recent emergence in Ghana.
M. Hamer, Katherine V. Houser, A. Hofstetter, Ana M. Ortega-Villa, Christine E Lee, Anne C Preston, Brooke Augustine, C. Andrews, G. Yamshchikov, S. Hickman, S. Schech, Jack N Hutter, P. Scott, Paige E. Waterman, M. Amare, Victor K. Kioko, C. Storme, K. Modjarrad, Melanie D. McCauley, M. Robb, M. Gaudinski, Ingelise J. Gordon, L. Holman, A. Widge, L. Strom, Myra Happe, J. Cox, Sandra Vazquez, Daphne A. Stanley, Tamar Murray, Caitlyn N. M. Dulan, Ruth Hunegnaw, S. Narpala, P. Swanson, Manjula Basappa, J. Thillainathan, M. Padilla, B. Flach, S. O'connell, Olga Trofymenko, P. Morgan, Emily E. Coates, J. Gall, A. McDermott, R. Koup, J. Mascola, Aurélie Ploquin, N. Sullivan, J. Ake, J. Ledgerwood   +49 more
semanticscholar   +1 more source

Marburg Virus Disease outbreaks, mathematical models, and disease parameters: a Systematic Review

medRxiv, 2023
Recent Marburg virus disease (MVD) outbreaks in Equatorial Guinea and Tanzania highlighted the importance of better understanding this highly lethal infectious pathogen.
G. Cuomo-Dannenburg, K. McCain, R. McCabe, H. Unwin, P. Doohan, R. K. Nash, J. Hicks, K. Charniga, C. Geismar, B. Lambert, D. Nikitin, J. Skarp, J. Wardle, Pathogen Epidemiology Review Group, M. Kont, S. Bhatia, N. Imai, S. V. van Elsland, A. Cori, Christian Morgenstern   +19 more
semanticscholar   +1 more source

Pathogenicity and virulence of Marburg virus

Virulence, 2022
Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death.
Mehedy Hasan Abir, Tanjilur Rahman, Ayan Das, Silvia Naznin Etu, Iqbal Hossain Nafiz, Ahmed Rakib, Saikat Mitra, T. Emran, K. Dhama, A. Islam, A. Siyadatpanah, S. Mahmud, B. Kim, M. Hassan   +13 more
semanticscholar   +1 more source

A bibliometric study on Marburg virus research with prevention and control strategies

Frontiers in Tropical Diseases, 2023
Marburg virus (MARV) is a pathogenic zoonotic RNA virus etiologic for Marburg virus disease (MVD), a severe hemorrhagic fever. This is a rare disease, with a high fatality rate, that spreads via infected blood or body fluids or indirectly via fomites ...
Md. Aminul Islam, S. Adeiza, M. R. Amin, Fatema Hasan Kaifa, J. Lorenzo, Prosun Bhattacharya, K. Dhama   +6 more
semanticscholar   +1 more source