Results 221 to 230 of about 852,364 (272)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Strategies Toward Accessing Enantioenriched (Hetero)Benzo‐Fused 5‐ and 6‐ Membered Rings via Intermolecular Carbometalation

Angewandte Chemie, EarlyView.
The use of transition‐metal catalysts and design of chiral ligands have allowed chemists to access highly functionalized benzofused 5‐ and 6‐ membered rings in high yield and enantioselectivity. A common strategy used relies on an intermolecular carbometalation across alkynes and olefins, usually followed by a subsequent intramolecular carbometalation.
Clara Jans, Armaan Grewal, Xavier Abel‐Snape, Mark Lautens   +3 more
wiley   +2 more sources

Analyzing genotype-environment interactions and identifying stable and high-yielding sorghum (Sorghum bicolor [L.] Moench) genotypes using different stability models. [PDF]

BMC Plant Biol
Tiruneh A, Bezabih A, Chakle S, Mulugeta T, Legesse A, Ayfokiru A, Temeche D, Abere E, Abebe A, Sisay T, Tefera N, Taye K.   +11 more
europepmc   +1 more source

Correction: Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila. [PDF]

PLoS Pathog
Cammarata-Mouchtouris A, Nguyen XH, Acker A, Bonnay F, Goto A, Orian A, Fauvarque MO, Boutros M, Reichhart JM, Matt N.   +9 more
europepmc   +1 more source

A Natural Recombinant NADC30-Like PRRSV Strain in China: Intersection of CH-1a, QYYZ, and JXA1 Lineages. [PDF]

Transbound Emerg Dis
Zhang H, Zhang C, Ma Y, Zhao Q, Wang X, Pan Q, Sun Y.   +6 more
europepmc   +1 more source

Two‐Dimensional Polymers as Modular Metal‐Free Solid‐State Catalysts for Efficient Sono‐Piezo‐Photocatalytic Hydrogen Peroxide Production

Angewandte Chemie International Edition, EarlyView.
This study demonstrates the high piezo‐photocatalytic activity of solid molecular catalysts (SMCs) in the production of hydrogen peroxide from water and oxygen. Through the rational design of molecular motifs (diphenylpyridine or terpyridine) and backbone functionalities (methyl group, aliphatic amine antenna, or aromatic pyrrole unit), as well as ...
Sarah Brettschneider, Keanu V. A. Birkelbach, Marcus Lantzius‐Beninga, Ahmed Mourran, Gurudas Chakraborty, Peter J. C. Hausoul, Andreas Herrmann, Regina Palkovits   +7 more
wiley   +1 more source

Setting up a multilingual & inclusive survey. [PDF]

Resusc Plus
Bilican S, Cox A, Schoenmakers B, Sabbe M, Salaets H.   +4 more
europepmc   +1 more source

o‐Terphenyl‐Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin

Angewandte Chemie International Edition, EarlyView.
This study presents the synthesis and binding properties of a new family of o‐terphenyl‐based macrocycles, TP[n] (n = 2‐8). The trimer variant efficiently binds phenylalanine in water with a 10‐fold selectivity compared to other amino acids and aromatic neurotransmitters.
Swapnil Ghule, Sayan Sarkar, Maria Eugenia Pérez‐Ojeda Rodriguez, Mark Spector, Frank Hampel, Evgeny A. Kataev   +5 more
wiley   +1 more source

Anxiety Suppressed Prefrontal Cortex Brain Activity: Insights From a Large Sample of Functional Near-Infrared Spectroscopy (fNIRS) Data. [PDF]

Depress Anxiety
Ren H, Wang Y, Yang Y, Xiao Q, Zhang Y, Wang F, Shi H, Potenza MN, Zhou D.   +8 more
europepmc   +1 more source