Results 231 to 240 of about 10,433,302 (306)

Infancy IgE methylation score and childhood wheezing and asthma: Multicohort study. [PDF]

J Allergy Clin Immunol
Yaskolka Meir A, Li Y, Zhu Z, Espinola JA, Hong X, Camargo CA, Wang X, Hasegawa K, Liang L.   +8 more
europepmc   +1 more source

Aromatic Pummerer‐Promoted Stereospecific Cross‐Coupling of Thiazoles With Boronic Esters

Angewandte Chemie, EarlyView.
A lithiation–borylation–aromatic Pummerer (LiBAP) strategy enables stereospecific, C5‐selective C(sp2)–C(sp3) cross‐coupling of thiazoles with boronic esters. By using exocyclic sulfoxide activation to overcome the low nucleophilicity that frustrates SEAr‐type coupling, the method delivers enantioenriched alkylated thiazoles bearing a versatile C2 ...
Mark John P. Mandigma, Julien Lefranc, Louise Eagling, Jasper L. Tyler, Varinder K. Aggarwal   +4 more
wiley   +1 more source

Whole cell inactivated poly-bacterial preparation MV130 effect on nasal mucosal immunity and experimental human pneumococcal carriage: double-blind randomised controlled trial with controlled human infection model. [PDF]

EBioMedicine
Ndaferankhande J, Jambo KC, Chikaonda T, Tembo G, Conejero L, Henrion MYR, Kudowa E, Lipunga G, Chirwa AE, Nsomba E, Mayuni MC, Mailboy M, Sigoloti A, Dzonzi B, Mangani E, Nkhoma V, Songolo S, Toto N, Thole F, Banda NPK, Galafa B, Kadzanja G, Kamanga MP, Chimgoneko L, Nthandira T, Tembo BM, Muyaya A, Makhaza L, Lipenga B, Katangwe V, Chiwala G, Grigg J, Gordon SB, MARVELS consortium.   +33 more
europepmc   +1 more source

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie, EarlyView.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +1 more source

Lectin-Based Antiviral Strategies for Porcine Reproductive and Respiratory Syndrome Virus 2 Infection: Griffithsin Suppresses Viral Replication In Vitro and Reduces Early Viremia In Vivo. [PDF]

Microorganisms
Kadekar D, Velayudhan D, Vinyeta E, Zhang J, Aljets E, Bamrung V, Sitthicharoenchai P, Michael A, Frogue K, Heng M, Liu A, Bongiorni C, Bhate M, Estell DA, Shen C, Poulsen C.   +15 more
europepmc   +1 more source

Engineering Ferrimagnetic Interactions in Molecular Quantum Systems

Angewandte Chemie, EarlyView.
Heterospin nanographene architectures—constructed by covalently linking spin‐1/2$\nicefrac {1}{2}$ and spin‐1 triangular units via on‐surface synthesis—are characterized by bond‐resolved scanning probe microscopy. Inelastic electron tunneling spectroscopy probes exchange interactions within a Heisenberg model, revealing both compensated (S=0$S=0$) and ...
Elia Turco, Fupeng Wu, Annika Bernhardt, Nils Krane, Ji Ma, Roman Fasel, Michal Juríček, Xinliang Feng, Pascal Ruffieux   +8 more
wiley   +1 more source

Effects of Non-Fermented Red Ginseng Marc in a Commercial Liquid Feeding System on Growth Performance, Fecal Short-Chain Fatty Acids, Blood Profiles, and Pork Quality in Growing Finishing Pigs. [PDF]

Animals (Basel)
Cui S, Wu A, Jin Y, Jin X.
europepmc   +1 more source

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, EarlyView.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +1 more source

Ferritinophagy Rewires Carnitine-Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication. [PDF]

Adv Sci (Weinh)
Guan K, Yuan C, Meng Z, Wang Y, Zhai X, Huang C, Zhou X, Zhang G.   +7 more
europepmc   +1 more source

Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry

Angewandte Chemie, EarlyView.
Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam, Kris Elbein, Aleida G. Gonzalez, Edgar A. Arriaga, Mark Nitz   +4 more
wiley   +1 more source