Unique evidence of fluid alteration in the Kakowa (L6) ordinary chondrite [PDF]
Scientific Reports, 2022 Meteorites preserve evidence of processes on their parent bodies, including alteration, metamorphism, and shock events. Here we show that the Kakowa (L6) ordinary chondrite (OC) preserves both shock-melt veins and pockets of detrital grains from a ...
I. P. Baziotis +8 more
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Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy [PDF]
Scientific Reports, 2023 Triple-negative breast cancers (TNBCs) are aggressive forms of breast cancer and tend to grow and spread more quickly than most other types of breast cancer.
Shengli Dong +6 more
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Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Solid tumor progression is significantly influenced by interactions between cancer cells and the surrounding extracellular matrix (ECM). Specifically, the cancer cell-driven changes to ECM fiber alignment and collagen deposition impact tumor growth and ...
Rakesh Gurrala +13 more
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Coaching People with Cardiovascular Disease to Close Their “Treatment Gaps” Reduces Hospital Utilization, Saves Lives, and Delivers Net Cost Savings Over 10 Years [PDF]
American Journal of Medicine OpenBackground: Disease management programs are an essential tool in the fight against rising prevalence and costs associated with cardiovascular disease (CVD).
Joshua Byrnes +4 more
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Correction: Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor. [PDF]
PLoS ONE, 2021 [This corrects the article DOI: 10.1371/journal.pone.0226464.].
Tiffany C Chang +15 more
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Liver Kinase B1 Regulates Remodeling of the Tumor Microenvironment in Triple-Negative Breast Cancer [PDF]
Frontiers in Molecular Biosciences, 2022 Liver kinase B1 (LKB1) is a potent tumor suppressor that regulates cellular energy balance and metabolism as an upstream kinase of the AMP-activated protein kinase (AMPK) pathway.
Connor T. King +15 more
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Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling [PDF]
Biomolecules, 2021 Extracellular signal-regulated kinase (ERK5) is an essential regulator of cancer progression, tumor relapse, and poor patient survival. Epithelial to mesenchymal transition (EMT) is a complex oncogenic process, which drives cell invasion, stemness, and ...
Akshita B. Bhatt +7 more
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Ceritinib is a novel triple negative breast cancer therapeutic agent [PDF]
Molecular Cancer, 2022 Background Triple-negative breast cancers (TNBCs) are clinically aggressive subtypes of breast cancer. TNBC is difficult to treat with targeted agents due to the lack of commonly targeted therapies within this subtype.
Shengli Dong +8 more
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Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer [PDF]
Translational Oncology, 2021 The epithelial to mesenchymal transition (EMT) is characterized by a loss of cell polarity, a decrease in the epithelial cell marker E-cadherin, and an increase in mesenchymal markers including the zinc-finger E-box binding homeobox (ZEB1).
Akshita B. Bhatt +10 more
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Key recommendations for developing a national action plan to advance the sexual and reproductive health and rights of women living with HIV in Canada [PDF]
Women's Health, 2022 Action on the World Health Organization Consolidated guideline on sexual and reproductive health and rights of women living with HIV requires evidence-based, equity-oriented, and regionally specific strategies centred on priorities of women living with ...
Angela Kaida +23 more
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