Results 71 to 80 of about 10,054,692 (312)
Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies
BMC Genetics, 2017 Background Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions.
Anke Hüls +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
The Responsiveness of Taxable Income to Changes in Marginal Tax Rates in Barbados [PDF]
Since 2003 policymakers in Barbados have implemented a series of tax reforms that have lowered both basic as well as marginal income tax rates. These changes have more than likely induced taxpayers to alter their behaviour in order to affect their ...
Moore, Winston
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Avaliação in vitro da adaptação marginal e interna de coroas cerâmicas confeccionadas com sistemas injetável e CAD/CAM [PDF]
, 2008 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em OdontologiaO objetivo deste estudo in vitro foi avaliar a adaptação marginal e interna de coroas cerâmicas confeccionadas com três ...
Barbosa, Marcelo Taveira
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The Effect of Marginal Tax Rates on Taxable Income: A Panel Study of the 1988 Tax Flattening in Canada [PDF]
Federal tax reform in 1988 flattened the Canadian personal income tax schedule, changing the marginal tax rates for many individuals. Using methods similar to those applied by Auten and Carroll (1999) in the study of the effects of the 1986 U.S.
Michael R. Veall, Mary-Anne Sillamaa
core +2 more sources
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
On hazard ratio estimators by proportional hazards models in matched-pair cohort studies
Emerging Themes in Epidemiology, 2017 Background In matched-pair cohort studies with censored events, the hazard ratio (HR) may be of main interest. However, it is lesser known in epidemiologic literature that the partial maximum likelihood estimator of a common HR conditional on matched ...
Tomohiro Shinozaki +2 more
doaj +1 more source
Frontiers in Dentistry, 2020 Objectives: This in-vitro study aimed to evaluate the effect of cavity disinfection with chlorhexidine (CHX) on marginal gaps of Class V composite resin restorations bonded with a universal adhesive using self-etch and etch-and-rinse bonding strategy ...
Soodabeh Kimyai +4 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Infiltração marginal em restaurações de resinas compostas modificadas por poliácidos, em molares decíduos: estudo "in vitro" / [PDF]
, 2000 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.O presente trabalho avaliou a infiltração marginal em restaurações classe II em molares decíduos.
Martinhon, Cleide Cristina Rodrigues
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