Results 81 to 90 of about 10,054,692 (312)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Marginal Man poster, circa 1988

, 1988
A poster for the Washington, D.C.
Sengers, Rachel
core  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Marginal revenue product and salaries: Moneyball redux [PDF]

Scully (1974) used a two equation regression model to estimate a baseball player’s salary to compare to the actual salary the player earned in order to determine if a player is paid his net marginal revenue product. We replicate the spirit of that paper,
Rockerbie, Duane W
core  

The Effect of Robot Adoption on Profit Margins

IEEE Transactions on Engineering Management
In this article, we examine the relationship between the degree of robot adoption and profit margins at countryindustry level for 25 European Union countries during the 19952017 period. We find evidence of a negative and U-shaped relationshiprobot adoption is negatively associated with profit margins, up to a point, before displaying a positive ...
Yifeng Philip Chen, Chander K. Velu, Duncan C. McFarlane   +2 more
openaire   +2 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

The Impact of Airline Differentiation on Marginal Cost Pricing at UK Airports [PDF]

, 2013
Airport pricing is a central issue in international transport policies, which tend to support pricing schemes based on marginal operating costs. This paper aims to provide empirical evidence in support of increased differentiation in airport charges on ...
Voltes Dorta, Augusto, Lei, Zheng, Augusto Voltes-Dorta, Voltes-Dorta, Augusto, Zheng Lei   +4 more
core   +1 more source

Stress Analysis on Hemispherical Head of Internal Pressure Vessel

Journal of Engineering
Since there is no unified equation of calculated stress near the marginal zone of cylindrical shell and its connected hemispherical head, this article first deduces calculated stress calculation equation near the marginal zone of hemispherical head ...
Mengzhao Long, Zhanhui Wang, Zhifang Zhang, Xiaojun Li   +3 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source