Results 51 to 60 of about 1,321,254 (310)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Chance Constrained Programming with Exponential Input Coefficients [PDF]
The Egyptian Statistical Journal, 2017 In this paper, we consider the chance constrained programming (CCP) technique when at least two of the LHS input coefficients are random with a two-parameter exponential distribution. Two approaches are introduced to transform CCP into deterministic: (i)
Nada Hafez, Afaf El-Dash, Nagwa Albehery
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Marginal Abatement Footprint Curves for Climate Change Mitigation
Chemical Engineering Transactions, 2022 Marginal abatement cost curves are widely used as an effective means of visualizing trade-offs between emissions reduction and cost. They involve plotting multiple mitigation options on rectangular coordinates, with cumulative abatement as the horizontal
Maria Victoria Migo-Sumagang +5 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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Capital Allocation Rules and Generalized Collapse to the Mean: Theory and Practice
MathematicsIn this paper, we focus on capital allocation methods based on marginal contributions. In particular, concerning the relation between linear capital allocation rules and the well-known Gradient (or Euler) allocation, we investigate an extension to the ...
Francesca Centrone +1 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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Technical and resource-use-efficiency among smallholder rice farmers in Northern Ghana
Cogent Food & Agriculture, 2019 This study seeks to estimate technical and resource-use efficiency in the Northern Region. Multistage sampling technique was used to collect cross-sectional data from 126 smallholder rice farmers in Tolon District of Northern Region, Ghana.
Dominic Tasila Konja +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
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