Results 71 to 80 of about 743,710 (334)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Journal of Mazandaran University of Medical Sciences, 2019 Background and purpose: One of the major challenges for dentists is providing the patients with a crown of appropriate marginal fit and marginal gap. Preparation of a 135° finish line has some advantages such as technical ease and appropriate finish line
Tahmineh Bamdadian +6 more
doaj
Marginal Fit of All-Ceramic Crown. Marginal Fit at Each Fabrication Step for Staining Technique.
Nihon Hotetsu Shika Gakkai Zasshi, 1997 This study was conducted to investigate how the ideal marginal fit of wax crown changes through the injecting, staining, glazing, and cementing procedures during fabrication of the IPS Empress crownby the staining technique for the upper first premolar tooth of the Dental Study Model (500 A, NISSIN DENTAL PRODUCTS, Japan).
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Fitness advice ignores realities of life on the margins [PDF]
Canadian Medical Association Journal, 2020 A single mother texts the neighbour who watches her two kids after school — she’ll be late picking them up because she missed the bus home from her second job. Waiting at the stop, she runs through her checklist of homework and chores to squeeze in before putting the kids to bed.
openaire +2 more sources
Marginal likelihoods in phylogenetics: a review of methods and applications
, 2019 By providing a framework of accounting for the shared ancestry inherent to all life, phylogenetics is becoming the statistical foundation of biology.
Cobb, Kerry A. +3 more
core
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source