Results 31 to 40 of about 8,860 (267)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Marginalisation and Exclusion of Women from the Church Governance Structures: Experience in Black South African Churches [PDF]
Pharos Journal of Theology, 2020 The marginalisation and, in extreme cases, the exclusion of women from the church governance structures, it has been observed, may be attributed to many stereotypes - perceptive, traditional, religious, to mention but a few. In the literature reviewed in
Dr Zandisile M. Dweba – PhD Candidate +2 more
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
“I thought I was going to pass”: Learners’ experiences of grade retention
South African Journal of Education, 2022 Grade retention is the practice of holding back learners who have failed to meet specific promotional requirements as stipulated by policy, in the same grade. The main objective of the research reported on here was to determine Foundation Phase (Grades 1–
Maureen Hadebe, Moeniera Moosa
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Quitter la France de Ariel Kenig o el extranjero en su piel. ¿En busca de una identidad? [PDF]
Çédille: Revista de Estudios Franceses, 2013 At the present time, globalisation has helped bridge the gap between citizens in many respects; nonetheless, it also seems to have driven a wedge between many people who now raise the issue of their identity in a country they can hardly recognise. We are
Rafael Ruiz Álvarez
doaj
Les mobilités douces dans l’architecture structurelle du réseau de transports à Abidjan : entre marginalisation et insécurité [PDF]
Revue de Géographie Tropicale et d’EnvironnementMarginalisées dans les politiques de transports, les mobilités douces se présentent aujourd’hui comme un enjeu de développement, d’attractivité territoriale et un levier d’action dans la lutte contre le changement climatique.
Emile Aurélien AHUA ; Armel Dimitry Komanan YAO
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source