Results 51 to 60 of about 39,297 (293)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Activism, Art-ivism and Digital Media to Reduce Marginalisation: Sharing Experiences and Lessons from Brazil, Kenya, Syria, and Costa Rica [PDF]

, 2019
This guide is part of the AHRC e-Voices: Redressing Marginality International Network(http://evoices.cemp.ac.uk). The project ran in 2018 and 219 and brought together a global network of academics and practitioners to explore the theme of marginalisation
Medrado, A., Rega, I.
core   +5 more sources

Is entrepreneurship a way out for the Moroccan youth?

Revista CIDOB d'Afers Internacionals, 2018
This article examines the entrepreneurial behaviour of the youth in urban and rural settings in Morocco. Based on the European research project SAHWA (2013–2016), and using a mixed methodology approach (ethnographic fieldwork and survey), an attempt is ...
Caroline Minialai, Lisa Bossenbroek, Driss Ksikes   +2 more
doaj   +1 more source

Understanding children’s constructions of meanings about other children: implications for inclusiveeducation

, 2008
This paper explores the factors that influence the way children construct meanings about other children, and especially those who seem to experience marginalisation, within school contexts.
Kyriaki Messiou, Messiou, Kyriaki
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Understanding vulnerability and resilience in Somalia

Jàmbá, 2020
In the recent years, Somalia witnessed a heightened frequency of droughts and conflicts. This article explores the experiences of Somalis during the 2011 and 2016 crises, examining the link between vulnerability and resilience, and the role played by ...
Charles Lwanga-Ntale, Boniface O. Owino
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

“I thought I was going to pass”: Learners’ experiences of grade retention

South African Journal of Education, 2022
Grade retention is the practice of holding back learners who have failed to meet specific promotional requirements as stipulated by policy, in the same grade. The main objective of the research reported on here was to determine Foundation Phase (Grades 1–
Maureen Hadebe, Moeniera Moosa
doaj   +1 more source