Results 31 to 40 of about 3,403 (265)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Quelles trajectoires pour les territoires ruraux d’étangs en Lorraine (1970 à nos jours) ?
Belgeo, 2017 This article considers the dynamics of the rural territories of ponds in Lorraine. The fragility and the marginality of these rural areas build two different trajectories around the poles of the pond.
Denis Mathis
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Acta Universitatis Carolinae Geographica, 2021 Serious problems are becoming evident after 20 years of liberalization concerning the development of Czech military training areas (MT As) and, in particular in their neighbouring zones.
Tomáš Seidl +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
(Re)drawing the limits of marginality
Nordic Journal of African Studies, 2019 Petina Gappah’s debut novel, The Book of Memory (2015), centres on the lives of two ‘white’ characters in post-independent Zimbabwe: Memory, the protagonist-narrator and a woman with albinism, and Lloyd, Memory’s adoptive father and a white, closeted ...
Gibson Ncube, Asante Lucy Mtenje
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Geografia socială a marginalităților: tipuri, clasificări, definiţii, repere teoretice și conceptuale [PDF]
Polis: Revista de Stiinte Politice, 2022 Often, the word „marginal”, – with its derivative „marginality” – evokes a world beyond the borders of our daily existence, somewhere else, far from the center of our lives, towards the abstract territories of the geographical, social, or human periphery.
Dan Mihai ȚĂLNARU
doaj
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source