Results 41 to 50 of about 22,724 (253)
História, Ciências, Saúde: Manguinhos, 2000 En este artículo propongo analizar las visiones de tres autores sobre la tuberculosis en la primera mitad del siglo XX y que en cierta medida reflejan la visión social sobre la enfermedad.
Adrián Carlos Alfredo Carbonetti
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Quelles trajectoires pour les territoires ruraux d’étangs en Lorraine (1970 à nos jours) ?
Belgeo, 2017 This article considers the dynamics of the rural territories of ponds in Lorraine. The fragility and the marginality of these rural areas build two different trajectories around the poles of the pond.
Denis Mathis
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
(Re)drawing the limits of marginality
Nordic Journal of African Studies, 2019 Petina Gappah’s debut novel, The Book of Memory (2015), centres on the lives of two ‘white’ characters in post-independent Zimbabwe: Memory, the protagonist-narrator and a woman with albinism, and Lloyd, Memory’s adoptive father and a white, closeted ...
Gibson Ncube, Asante Lucy Mtenje
doaj +1 more source
(Un)caring communities: processes of marginalisation and access to formal and informal care and assistance in rural Russia [PDF]
, 2011 The marginality of rural life, understood in structural, economic, political and geographic terms, has been an underlying theme in both historical and contemporary studies of the Russian countryside.
Kay, R., Rebecca Kay
core +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
The dynamics of marginality in continuing higher education.
, 1989 The dynamics of marginality in continuing higher ...
Dean F. Eitel (7999700)
core +5 more sources