Results 41 to 50 of about 3,258 (246)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Geografia socială a marginalităților: tipuri, clasificări, definiţii, repere teoretice și conceptuale [PDF]
Polis: Revista de Stiinte Politice, 2022 Often, the word „marginal”, – with its derivative „marginality” – evokes a world beyond the borders of our daily existence, somewhere else, far from the center of our lives, towards the abstract territories of the geographical, social, or human periphery.
Dan Mihai ȚĂLNARU
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Ulikhet, marginalisering og politikk: erfaringer fra russiske monobyer
Nordisk ØstforumThis paper addresses inequality and marginality in Russia through an urban lens. Mono-industrial cities, in short “monotowns”, are attractive locations for this research because of the legacy of city-building enterprises, industrial reconstruction, and ...
Kirsti Stuvøy
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Being educators in extreme contexts. When practice challenges theory
Ricerche di Pedagogia e Didattica, 2018 Educating in extreme contexts means accomplishing a challenge with at the same time different degrees of complexity and difficulty. Of course, the skills and professionalism of an educator (professional, teacher, children’s entertainer) who works in such
Francesco Lo Presti, Fausta Sabatano
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
“We are all souls”: Dogs, dog-wo/men and borderlands in Coetzee and Tyulkin
Tydskrif vir Letterkunde, 2018 Examining the notion of “dog-men” in Coetzee’s Disgrace and Tyulkin’s documentary Not about Dogs, I argue that when the main characters become dog-men and dog-women they share with dogs the status of subaltern border-creatures.
Henrietta Mondry
doaj +1 more source