Results 31 to 40 of about 87,704 (248)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Marginalisation and stereotypes relating to the elderly in the context of social changes and family problems. Generation gap and methods of prevention in Poland

Journal of Modern Science
Objectives The general aim of the present study is the sociological conceptualization of the problem of social marginalization and stereotypes relating to old people by the analysis of the “generation gap”, its factors and indicators as well as ...
Bartosz Łukaszewski, Leon Szot, Mirosław Kalinowski, Iwona Niewiadomska   +3 more
doaj   +1 more source

Regard sur la participation de populations marginalisées à la recherche-action. Le cas des squatteurs en Ile-de-France

Revue Interventions Économiques, 2011
Research-Action has two main objectives: to allow different players to cooperate, and to transform social reality. This methodology has both the strengths and the weaknesses of strictly cognitive research.
Anne Petiau, Lionel Pourtau
doaj   +1 more source

Religious Indoctrination or Marginalization Theory? Muslim-Christian Public Discourses and Perceptions on Religious Violence in Kenya [PDF]

Journal for the Study of Religion, 2017
The numerous killings of non-Muslims by Muslim jihadi groups in Kenya, have fuelled ethno-religious tensions manifested in hatred and anger against the entire Muslim community.
Hassan J. Ndzovu
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Care, co-survival, and decency: expanding the understanding of outdoor life and smaller alcohol and drug scenes in Denmark and Norway

Frontiers in Psychiatry
IntroductionPublic spaces where alcohol and other drugs are openly used and marginal citizens gather, exist in many Nordic cities. The biggest open drug scenes in the Nordic countries are in cities like Oslo and Copenhagen; however, there are smaller ...
Jonas Strandholdt Bach, Trond Erik Grønnestad, Anne Schanche Selbekk, Anne Schanche Selbekk, Vilde Holan Bye, Amanda Skjong   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Risk Aversion and Double Marginalization [PDF]

, 2018
In vertical markets, eliminating double marginalization with a two-part tariff may not be possible due to downstream firms\u27 risk aversion. When demand is uncertain, contracts with large fixed fees expose the downstream rm to more risk than contracts ...
Ghili, Soheil, Schmitt, Matthew
core   +1 more source

Teaching Music History in the Margins

Musica Docta, 2019
Music history is often pushed to the margins of the public school curriculum. Faced with limited time and resources, teachers need to find concise, non-traditional ways to reintegrate history with performance and the other liberal arts. At the same time,
James A. Davis, Jessica Lotyczewski, Henryk Lotyczewski   +2 more
doaj   +1 more source