Results 41 to 50 of about 58,824 (265)

Retrospective multicenter study on severely dysplastic melanocytic nevi: evaluating the need for re-excision and the risk of recurrence or progression

Dermatology Reports
Severely dysplastic melanocytic nevi (SMD) are histologically challenging lesions with no consensus on optimal management. While complete excision is widely recommended, the necessity of additional reexcision remains debated.
Cesare Ariasi, Carlo Cota, Cesare Massone, Carmine D'Acunto, Pietro Danese, Maurizio Lombardo, Davide Melandri, Francesca Scarpellini, Rosa Rinaldi, Paola Pasquini, Paolo Incardona, Piergiacomo Calzavara-Pinton, Paola Monari   +12 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Safety Margin in Excision of Basal Cell Carcinoma

Pakistan Journal of Biological Sciences, 2009
The aim of this study was to evaluate the intact margin after surgery regarding common method with consideration of 4 mm safe margin. Fifty patients with basal cell carcinoma operated in Tabriz Sina hospital, were chosen randomly and pathological report of these patients after surgery was evaluated with consideration of presence of intact margin.
S, Babaye-Nazhad, M, Amirnia, H, Alikhah, E, Khodaeyani, N, Atapour   +4 more
openaire   +2 more sources

Preoperative localisation of nonpalpable breast lesions using magnetic markers in a tertiary cancer centre

European Radiology Experimental, 2022
Background We retrospectively evaluated safety and performance of magnetic seed localisation of nonpalpable breast lesions. Methods We reviewed records of patients with nonpalpable breast lesions preoperative localised by placing magnetic Magseed® marker
Antonella Petrillo, Raimondo Di Giacomo, Emanuela Esposito, Paolo Vallone, Sergio Venanzio Setola, Mauro Mattace Raso, Vincenza Granata, Maria Luisa Barretta, Claudio Siani, Chiara Rinaldo, Ivana Donzelli, Ugo Marone, Maria Teresa Melucci, Alfredo Fucito, Ruggero Saponara, Maurizio Di Bonito, Roberta Fusco, Massimo Rinaldo, Franca Avino   +18 more
doaj   +1 more source

Rate of Involved Endocervical Margins According to High-Risk Human Papillomavirus Subtype and Transformation Zone Type in Specimens with Cone Length ≤ 10 mm versus > 10 mm—A Retrospective Analysis

Life, 2023
The aim of this study was to evaluate the endocervical margin status according to transformation zone (TZ) and high-risk HPV (hr-HPV) subtype in specimens with cone length ≤ 10 mm versus > 10 mm to provide data for informed decision making and patients ...
Chiara Paternostro, Elmar A. Joura, Christina Ranftl, Eva-Maria Langthaler, Robin Ristl, Tim Dorittke, Sophie Pils   +6 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Marginal Excision of Atypical Lipoma of the Forearm

Annals of African Medicine
Abstract Atypical lipomatous tumor is a well-differentiated liposarcoma which is locally aggressive but does not typically metastasize. Atypical lipoma of the forearm is a very rare condition with unknown incidence. The management of atypical lipoma of the forearm is controversial, with some authors suggesting
Mada Sai, Krishna, Polisetty V Shyam, Prasad, Krishna Chaitanya Reddy, Yerraguntla, Hardiksinh Jitendrasinh, Solanki   +3 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source