Results 191 to 200 of about 597,708 (293)

Whole Blood Transcriptomic Analysis of Sickle Cell Trait

European Journal of Haematology, EarlyView.
ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson, Yanwei Cai, Ana Gabriela Vasconcelos, Peter Orchard, Paul L. Auer, Guillaume Lettre, Jia Wen, Nora Franceschini, Charles Kooperberg, Wei Sun, Li Hsu, Laura M. Raffield, Alex P. Reiner   +12 more
wiley   +1 more source

Unlocking female CEOs' contribution to the internationalization of family‐controlled firms

European Management Review, EarlyView.
Abstract Are female CEOs better or worse than male CEOs for the internationalization of family‐controlled firms? By addressing this question, we draw on Upper Echelons Theory (UET) and complement it with insights from the Behavioral Theory of the Firm (BTF) to examine the moderating role of governance and ownership openness. Using a large panel of 2150
Alfredo D'Angelo, Fabio Quarato, Domenico Rocco Cambrea, Pasquale Latella   +3 more
wiley   +1 more source

Correction to European Consensus on Functional Bloating and Abdominal Distension-ESNM/UEG Recommendations for Clinical Management. [PDF]

United European Gastroenterol J
europepmc   +1 more source

Development of a cost-effectiveness analysis model for Duchenne muscular dystrophy utilizing the national registry in Japan. [PDF]

Sci Rep
Okada T, Komaki H, Ishizuka T, Oba M, Hori S, Nakamura H.   +5 more
europepmc   +1 more source

Bexicaserin for the treatment of seizures in developmental and epileptic encephalopathies: A phase 1b/2a trial (PACIFIC)

Epilepsia, EarlyView.
Abstract Objective This randomized, double‐blind, phase 1b/2a clinical trial was designed to evaluate the safety, tolerability, and efficacy of oral bexicaserin versus placebo for the treatment of seizures in adolescents and adults with developmental and epileptic encephalopathies (DEEs).
Dennis J. Dlugos, Ingrid E. Scheffer, Jacqueline A. French, David G. Vossler, Chad Orevillo, Shikha Polega, Randall Kaye, and the LP352‐201 Study Investigators, Kore Liow, Ena Zhu, Jennifer Waldron, Hayley Groubert, Alexis Anderson, Pavel Klein, Salman Hashmi, Shicong Ye, Anita Farhi, David Vossler, Dione M. Froman, Shannon L. Hoffman‐Huffaker, Ki Hyeong Lee, AnnaLyn Dallas, Amir Arain, Laura Beeler, Michael Macken, Irena Bellinski, Elizabeth Cunningham, James Renfroe, Shezsay Colbert, Robert Hogan, Patty Schaefer, Susan Shaw, Sheetal Desai, Ahmed Sadek, Haile Robertson, Kamil Detyniecki, Anabela Cieslicki, Ruben Kuzniecky, Sarah Goodman, Selim Benbadis, Marina Azevedo, Sami Aboumatar, Julie Biel, Nilika Singhal, Emerald Wan, Evan Fertig, Hannah Hart, Debopam Samanta, Sarah Hankins, Steven Wolf, Patricia Pena, Robert Nahouraii, M. J. Mari, David Burdette, Stephanie Mueller, Karen Keough, Victoria Henderson, Talitha Durgin, Terence O’Brien, Rafael Smith, Jack Germaine, Kate Riney, Lori Anthony, David Reutens, Kimberley Irwin, Michael Fahey, Melissa Batt, Stephanie Kaladis, Kasthoori Jeyachanthiran, Ingrid Scheffer, Rebecca Wharrie, Greesha Zacharia, Brittany Walsh, Heather Robinson, Sharon Ganter   +74 more
wiley   +1 more source

Evaluation of a dressing film for ultrasound-guided vascular puncture to achieve high-quality imaging and infection prevention. [PDF]

J Ultrasound
Abe M, Takahashi T, Muta M, Kawamoto A, Murayama R, Nakagami G.   +5 more
europepmc   +1 more source

Risk factors associated with owner‐reported sleep disturbances in Nordic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Very little is known about sleep disturbances in horses, although several management or animal‐based factors may contribute to an increased risk of disturbances. Objectives To investigate factors related to rest and sleep behaviour of horses kept in stalls as perceived by Nordic horse owners or caretakers and their association with ...
H. Suomala, I. Brotherus, L. Hänninen, E. Ternman, A. K. Mykkänen   +4 more
wiley   +1 more source

Atypical Pediatric-Onset Behçet's Disease Presenting With Superior Vena Cava Thrombosis in an Adolescent Male: A Case Report. [PDF]

Clin Case Rep
Ullah U, Mari T, Ullah Mian U, Ali A, Aleem S, Lal T, Moeez A, Begum T, Ikram J.   +8 more
europepmc   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source