Results 11 to 20 of about 4,688 (187)

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype

EMBO Molecular Medicine, 2021
Batten diseases (BDs) are a group of lysosomal storage disorders characterized by seizure, visual loss, and cognitive and motor deterioration. We discovered increased levels of globotriaosylceramide (Gb3) in cellular and murine models of CLN3 and CLN7 ...
Chiara Soldati, Irene Lopez‐Fabuel, Luca G Wanderlingh, Marina Garcia‐Macia, Jlenia Monfregola, Alessandra Esposito, Gennaro Napolitano, Marta Guevara‐Ferrer, Anna Scotto Rosato, Einar K Krogsaeter, Dominik Paquet, Christian M Grimm, Sandro Montefusco, Thomas Braulke, Stephan Storch, Sara E Mole, Maria A De Matteis, Andrea Ballabio, Julio L Sampaio, Tristan McKay, Ludger Johannes, Juan P Bolaños, Diego L Medina   +22 more
doaj   +1 more source

Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma

Frontiers in Oncology, 2020
Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabolites
Soudabeh Rad Pour, Hiromasa Morikawa, Narsis A. Kiani, Narsis A. Kiani, David Gomez-Cabrero, David Gomez-Cabrero, Alistair Hayes, Xiaozhong Zheng, Maria Pernemalm, Janne Lehtiö, Damian J. Mole, Johan Hansson, Johan Hansson, Hanna Eriksson, Hanna Eriksson, Jesper Tegnér, Jesper Tegnér, Jesper Tegnér   +17 more
doaj   +1 more source

The Use of Problem-Based Learning Physics E-Module on Global Warming Material: High School Students Perception

Journal of Innovative Science Education, 2023
Global warming as one of the physics materials, is a topic that tends to be abstract so it causes difficulties for students. In addition, limited time for learning activities in class is an obstacle to achieving optimal understanding.
Julius Wilson, Paulina Nelce Mole, Maria Bernadetha Dua Riong   +2 more
doaj  

Case report of oxalate nephropathy in a patient with pancreatic metastases from renal carcinoma

BMC Cancer, 2019
Background Patients with metastatic renal carcinoma frequently have pre-existing renal impairment and not infrequently develop worsening renal function as a complication of their treatment.
Karin Purshouse, Sarah Chamberlain, Maria Soares, Mark Tuthill, Andrew Protheroe, David R. Mole   +5 more
doaj   +1 more source

Correction: Magmas Overexpression Inhibits Staurosporine Induced Apoptosis in Rat Pituitary Adenoma Cell Lines.

PLoS ONE, 2013
[This corrects the article on p. e75194 in vol. 8.].
Federico Tagliati, Teresa Gagliano, Erica Gentilin, Mariella Minoia, Daniela Molè, Ettore C Delgi Uberti, Maria Chiara Zatelli   +6 more
doaj   +1 more source

Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κB

Cellular Oncology, 2009
Background: Breast cancer cells can develop chemoresistance after prolonged exposure to cytotoxic drugs due to expression of the multi drug resistance (MDR) 1 gene.
Maria Chiara Zatelli, Daniela Molè, Federico Tagliati, Mariella Minoia, Maria Rosaria Ambrosio, Ettore Degli Uberti   +5 more
doaj   +1 more source

Spatial and temporal distribution of weeds in no-tillage system

Revista Brasileira de Engenharia Agrícola e Ambiental
Brazil is one of the largest grain producers in the world, due to its extensive arable land and favorable climate for the cultivation of any species. The production could be higher, but problems such as competition between crops and weeds reduces crop ...
Eduardo L. Bottega, Camilo Pegoraro, Naiara Guerra, Antonio M. de Oliveira Neto, Daniel M. de Queiroz   +4 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source