Results 31 to 40 of about 2,708 (249)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Toward a common approach for assessing the conservation status of marine turtle species within the european marine strategy framework directive

Frontiers in Marine Science, 2022
Environmental policies, including the European Marine Strategy Framework Directive (MSFD), generally rely on the measurement of indicators to assess the good environmental status (GES) and ensure the protection of marine ecosystems. However, depending on
Fanny Girard, Alexandre Girard, Alexandre Girard, Alexandre Girard, Jonathan Monsinjon, Antonella Arcangeli, Eduardo Belda, Luis Cardona, Paolo Casale, Sidonie Catteau, Léa David, Florence Dell’Amico, Delphine Gambaiani, Marc Girondot, Imed Jribi, Giancarlo Lauriano, Paolo Luschi, David March, David March, Antonios D. Mazaris, Claude Miaud, Claude Miaud, Andreas Palialexis, Jacques Sacchi, Ricardo Sagarminaga, Paola Tepsich, Jesús Tomás, Frederic Vandeperre, Frederic Vandeperre, Françoise Claro   +29 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Marine Geographic Information Systems, Spatial Analysis Tools in the Management Process of Spanish Marine Protected Areas

ISPRS International Journal of Geo-Information
Spain’s extensive marine jurisdiction—comprising a continental shelf of approximately 100,000 km2 and an Exclusive Economic Zone approaching one million km2—requires robust geospatial frameworks to support ecosystem assessment and marine policy ...
Dulce Mata, Paula Gil, Ángela Bellido, Olvido Tello   +3 more
doaj   +1 more source

Detecting critical choke points for achieving Good Environmental Status in European seas

Ecology and Society, 2015
Choke points are social, cultural, political, institutional, or psychological obstructions of social-ecological systems that constrain progress toward an environmental objective.
Tavis Potts, Tim O'Higgins, Ruth Brennan, Sergio Cinnirella, Urs Steiner. Brandt, Juan Luís Suárez de Vivero, Justus van Beusekom, Tineke A. Troost, Lucille Paltriguera, Ayse Gunduz Hosgor   +9 more
doaj   +1 more source

A Drop in the Ocean: Patchy Evidence on the Societal Benefits of Marine Litter Reduction

Frontiers in Marine Science, 2021
The benefits of marine litter reduction to society, which are mostly non-market ones, need to be valued and quantified in monetary terms to be included in cost benefit analyses required by the EU Marine Strategy Framework Directive.
Jana Stoever, Katrin Rehdanz, Ikechukwu Charles Okoli   +2 more
doaj   +1 more source

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

Marine Strategy Framework Directive - Descriptor 3+ (MSFD D3) [PDF]

, 2012
Revised 22 February 2012. This report describes the process undertaken by ICES to provide guidance to support EU Member States (MS) in the implementation of the Marine Strategy Framework Di-rective (MSFD) Descriptor 3 (D3), commercially exploited fish and shellfish. The re-port also describes the potential role of ‘ecosystem’ indicators collected under
openaire   +1 more source

Structuring social data for the Marine Strategy Framework Directive

Marine Policy, 2014
The Marine Strategy Framework Directive, adopted by the EU, and several other initiatives to improve marine environmental management emphasize the need to integrate environmental and social analyses. This article proposes and tests a general Behavior-Pressure-State-Impact-Response (BPSIR) framework for identifying and structuring environmentally ...
Sundblad, Eva-Lotta, Grimvall, Anders, Gipperth, Lena, Morf, Andrea   +3 more
openaire   +1 more source

Implementing and innovating marine monitoring approaches for assessing marine environmental status

Frontiers in Marine Science, 2016
Marine environmental monitoring has tended to focus on site-specific methods of investigation. These traditional methods have low spatial and temporal resolution and are relatively labour intensive per unit area/time that they cover.
Roberto Danovaro, Roberto Danovaro, Laura Carugati, Marco Berzano, Abigail E. Cahill, Abigail E. Cahill, Susana Carvalho, Anne CHENUIL, Cinzia Corinaldesi, Sonia Cristina, Sonia Cristina, Romain R.DAVID DAVID, Antonio Dell'Anno, Nina DZHEMBEKOVA, Esther Garcés, Josep M Gasol, Priscila Goela, Priscila Goela, Jean-Pierre FERAL, Isabel Ferrera, Rodney Forster, Andrey A. Kurekin, Eugenio Rastelli, Veselka Marinova, Peter I. Miller, Snejana Moncheva, Alice Newton, John Kenneth Pearman, Sophie Genevieve Pitois, Albert Renè, Naiara Rodriguez-Ezpeleta, Vincenzo Saggiomo, Stefan G.H. Simis, Stefan G.H. Simis, Kremena Stefanova, Christian Wilson, Marco Lo Martire, Marco Lo Martire, Silvestro Greco, Sabine Cochrane, Angel Borja   +40 more
doaj   +1 more source