Results 191 to 200 of about 3,114 (254)

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

Advocating microbial diversity conservation in Antarctica. [PDF]

NPJ Biodivers
Zucconi L, Fierro-Vásquez N, Antunes A, Bendia AG, Lavin P, González-Aravena M, Sani RK, Banerjee A.   +7 more
europepmc   +1 more source

Advances and Challenges in Micro/Nanocarrier‐Based Dermal Drug Delivery Systems for Acne Treatment

Advanced NanoBiomed Research, EarlyView.
Topical acne treatment faces challenges from skin barriers and complex causes. Micro/nanocarriers improve drug delivery by enhancing bioavailability, targeting, and duration. Combining carriers creates synergistic effects for systematic intervention.
Jintao Yang, Jie Chen, Yunmiao Ma, Qingwei Zhou, Yu Kong, Yingxiang Chen, Junjie Chi, Haihua Hu   +7 more
wiley   +1 more source

On the Discorhabdins Leading to the Aleutianamine Ring System: A One‐Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology

Angewandte Chemie, EarlyView.
The thiocarbenium ion rearrangement of 3‐dihydrodisorhabdin B greatly increases the recovery of aleutianamine from Latrunculia spp., a pyrroloiminoquinone natural product with potent activity against drug‐resistant cancers, collected from the deep‐ocean along the Aleutian Islands.
Cody F. Dickinson, Abhay Potluri, Alison M. Bland, Samuel M. Flipse, George S. Hanna, Ryan T. Wagner, Keith D. Robertson, Thai H. Ho, Daniel J. Sprague, Gerald R. Hoff, Robert P. Stone, Marcus A. Tius, Dean J. Tantillo, Mark T. Hamann   +13 more
wiley   +2 more sources

Maternal and paternal lineage analysis of Island Southeast Asian goats reveals continental propagation routes and introgression through the Indian ocean. [PDF]

Sci Rep
Masuko R, Ayin, Masaoka M, Kawaguchi F, Sasazaki S, Dagong MIA, Bugiwati SRA, Masangkay JS, Yonezawa T, Mannen H.   +9 more
europepmc   +1 more source

The diurnal cycle of precipitation over the Maritime Continent

The archipelago straddling the equator between the Indian and Pacific Oceans, known as the Maritime Continent (MC), is a broad region experiencing very high mean precipitation rate. Powerful global circulation cells are driven by the significant latent heat released over the MC.
openaire   +1 more source

Bond Softening and Elastic Confinement of Monolithic Dense Binary Alloys for High Volumetric Capacity of K‐Ion Battery Anodes

Angewandte Chemie, EarlyView.
Synergistically intrinsic‐extrinsic dual‐stabilization engineering to construct dense monolithic alloy architectures is proposed by integrating 2D binary alloy nanosheets into 3D elastic graphene networks. Such a dense monolithic anode achieves high volumetric and areal performance, enabling fast K+ transfer and superior structural recovery during ...
Yunyong Li, Yiru Zhou, Bingchun Wang, Xinying Wang, Lei Liu, Zhuhang Shao, Hao Wu, Zaowen Zhao, Yingqiang Wu, Xuerong Zheng, Xinwei Li, Wenwu Li, Yida Deng, Zaiping Guo, Ho Seok Park   +14 more
wiley   +2 more sources

Detection of Communications Channels in VHF Band for Enhanced Maritime Surveillance. [PDF]

Sensors (Basel)
Lopes A, Fernandes L, Chaves P.
europepmc   +1 more source

Heterogeneities in landed costs of traded grains and oilseeds contribute to unequal access to food. [PDF]

Nat Food
Verschuur J, Vittis Y, Obersteiner M, Hall JW.   +3 more
europepmc   +1 more source

Structural Correlation Coefficient for Polymer Structural Composites-Reinforcement with Hemp and Glass Fibre. [PDF]

Polymers (Basel)
Scheibe M, Urbaniak M, Bledzki A.
europepmc   +1 more source