Results 121 to 130 of about 519,075 (297)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Temporal adaptive neural ordinary differential equations with deep spatio-temporal point processes for real-time network intrusion detection

Complex & Intelligent Systems
Network attacks exploit complex temporal dependencies spanning microseconds to months, requiring unified modelling of continuous system dynamics and discrete event occurrences.
Roger Nick Anaedevha, Alexander Gennadievich Trofimov, Yuri Vladimirovich Borodachev   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Uniform limit theorems for marked point processes

Stochastic Processes;Limit Theorems;60G10;60F15;60G55;probability ...
Nieuwenhuis, G.
core  

Research on the Self-Organized Criticality and Fracture Predictability of Sandstone via Real-Time CT Scanning and AE Monitoring

Applied Sciences
Progressive damage evolution in rock masses serves as the fundamental mechanism driving geological hazards by controlling deformation patterns and failure predictability. To address the critical challenge of predicting fracture behaviors in heterogeneous
Huimin Yang, Yongjun Song, Jianxi Ren, Yiqian Chen   +3 more
doaj   +1 more source

Transaction component of exogenous factors of influence upon employment under conditions of globalisation of economy [PDF]

Problemi Ekonomiki, 2013
The goal of the article lies in identification of influence of globalisation upon efficiency of financial and loan instruments that ensure regulation and stimulation of employment and the role of transaction costs in these processes. To achieve the goal,
Glushach Anna V., Arkhiyeryeev Sergey I.
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dominated Families of Shifted Palm Distributions

In stationary point process theory, the concept Palm distribution plays an important role.Many important results (like for instance Little s law, so important in many fields) arise from it.However, in the non-stationary case a whole family of local Palm ...
Nieuwenhuis, G.
core  

Critical approach to the jurist's historical formation in the systems of western Right

Revista MENDIVE, 2012
The jurist's historical formation has been marked by the system of Right in that the curriculum of the career is framed. In occident the Anglo-Saxon system and the Roman - French one prevail, in one the historical contents are nurtured of the judicial ...
Alie Pérez Véliz, Teresa Díaz Domínguez   +1 more
doaj  

Characteristics of Energy Evolution and Failure Mechanisms in Sandstone Subject to Triaxial Cyclic Loading and Unloading Conditions

Applied Sciences
This study investigates the energy dynamics of sandstone subjected to failure in conditions typical of deep underground construction. Research was conducted using both standard triaxial compression and cyclic loading–unloading techniques at six distinct ...
Jinrui Zhang, Yi Luo, Hangli Gong, Xianqi Zhang, Shankun Zhao   +4 more
doaj   +1 more source