Results 111 to 120 of about 19,662 (283)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Blind Alley Developments in Childrens’ Language Acquisition

Encyclopedia
A blind alley development (BAD) is a rarely occurring ephemeral development of young children that systematically deviates from parental input and is eventually abandoned due to persistent explicit and/or implicit correction by the children’s caregivers.
Wolfgang U. Dressler
doaj   +1 more source

Gathering Statistics to Aspectually Classify Sentences with a Genetic Algorithm

, 1996
This paper presents a method for large corpus analysis to semantically classify an entire clause. In particular, we use cooccurrence statistics among similar clauses to determine the aspectual class of an input clause.
McKeown, Kathleen R., Siegel, Eric V.
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Markedness as figure-ground manipulation: a hypothesis

Cognitive Linguistics
Markedness in language has been a perpetual fascination for linguists of all persuasions, but a unified account of it has proven elusive. In this paper, I propose a figure-ground gestalt (FGG) hypothesis, arguing that markedness is a mechanism for ...
Chen Rong
doaj   +1 more source

Paul de Lacy, Markedness: Reduction and preservation in phonology (Cambridge Studies in Linguistics 112). Cambridge: Cambridge University Press, 2006. Pp. xviii+447. [PDF]

, 2010
Nevins, A, Plaster, K
core   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Choice of classifier handshape in Catalan Sign Language: A corpus study

Open Linguistics
Classifier predicates are sign language modality specific constructions that are widely spread in all attested sign languages. Extended research has been devoted to the study of these structures, but many aspects related to their nature remain unclear ...
Zorzi Giorgia, Veiga Busto Raquel, Barberà Gemma, Navarrete-González Alexandra, Quer Josep   +4 more
doaj   +1 more source

Weak function word shift [PDF]

, 2004
The fact that object shift only affects weak pronouns in mainland Scandinavian is seen as an instance of a more general observation that can be made in all Germanic languages: weak function words tend to avoid the edges of larger prosodic domains.
Vogel, Ralf
core  

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source