Results 101 to 110 of about 1,724,316 (324)

Marked or unmarked, that is not the question. The question is: where’s the theme? Marked or unmarked, that is not the question. The question is: where’s the theme?

open access: yesIlha do Desterro, 2008
The definition of theme is not entirely uncontroversial within systemic linguistics. Furthermore, the application of the notion of theme to languages other than English is even more problematic.
Carlos A. M. Gouveia, Leila Barbara
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Are there brain bases for phonological markedness?

open access: yes, 2017
Pursuing the question of whether there are brain bases for phonological markedness necessitates an empirical and testable approach. This approach – put forward in this chapter – is couched in a theory of phonological feature specification and tested with
Scharinger, M.
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Covert contrast as a developmental stage in L2 phonology: evidence from Arabic emphatics

open access: yesCogent Arts & Humanities
This study examines covert contrasts—acoustically distinct yet imperceptible phonemic differences—in English-speaking learners of Modern Standard Arabic, focusing on /tˤ/–/t/ and /sˤ/–/s/.
Mohammad Aljutaily, Radhyah Almutairi
doaj   +1 more source

The Syncategorematic Nature of Neo-Aramaic and English Antonyms

open access: yesLinguistic Discovery, 2018
Antonyms have always been considered the starting point for language learners; therefore, they are familiar cross-linguistically. In this research, we try to provide a semantic description of antonymy in Neo-Aramaic (a member of the Semitic family) as it
Ala Al-Kajela
doaj   +1 more source

Interactions Between Markedness and Faithfulness Constraints in Vowel Systems

open access: yes
Miglio argues that to assess the relative markedness of a segment, frequency of occurrence in vowel inventories is insufficient when considered on its own.
Giulia Miglio, Viola.
core  

Scat syllables and markedness theory

open access: yes, 2008
A highly creative domain between the prosodies of human language and the riffs of instrumental jazz is the dynamic vocal jazz idiom of scat. The present analysis proceeds from the observation that, despite the distinctly individualistic approaches to ...
Shaw, Patricia A.
core  

A study of markedness in second language acquisition [PDF]

open access: yes, 1986
This study was set up to investigate the role of markedness in the acquisition of a second language. The definition of markedness chosen was in agreement with that of the Prague School, and in particular with the work of Trubetzkoy (1939), Jakobson ...
Pavesi, Maria Gabriella
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

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