Results 81 to 90 of about 1,724,316 (324)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2009 This paper reports the results of a corpus investigation on case conflicts in German argument free relative constructions. We investigate how corpus frequencies reflect the relative markedness of free relative and correlative constructions, the relative ...
Zugck, Marco, Vogel, Ralf
core
Language specific markedness: The case of place of articulation [PDF]
, 2003 In this paper I draw on evidence from familiar criteria for diagnosing markedness values to argue that markedness is best determined on a language specific basis.
Hume, E.
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Some inventory-related asymetries in the patterning of tongue root harmony systems
Studies in African Linguistics, 2016 Earlier studies (e.g., Casali 2003, 2008) have presented evidence of significant differences in assimilatory tendencies in vowel systems that have an [ATR] contrast in high vowels (“/2IU/ systems”) and those that have an [ATR] contrast only in non-high ...
Roderic F. Casali
doaj +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Comparative markedness (long version)
, 2002 The markedness constraints of classic Optimality Theory assign violation-marks to output candidates without reference to the input or to other candidates.
McCarthy, John J
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Word Order and Markedness in a Slovenian Poem and Its English Translations
ELOPE, 2004 When systemic differences between languages preclude the possibility of a truly “faithful” translation, the translator may choose to preserve either the form of the original, that is its syntactic structure, or its function, which includes not only the ...
Nada Grošelj
doaj +1 more source