Results 111 to 120 of about 1,724,316 (324)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Coseriu et Hjelmslev sur la théorie de la marque. Éléments pour continuer le dialogue

Histoire Épistémologie Langage
One may rightly assume that Eugenio Coseriu’s integral linguistics and Louis Hjelmslev’s glossematics represent two keys to a mutual understanding. On the one hand, Coseriu’s criticism towards certain aspects of glossematics proves useful for better ...
Lorenzo Cigana
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Substitution Errors and the Role of Markedness in Bilingual Phonological Acquisition. [PDF]

J Speech Lang Hear Res, 2023
Sieg SR, Fabiano L, Barlow J.
europepmc   +1 more source

Markedness as figure-ground manipulation: a hypothesis

Cognitive Linguistics
Markedness in language has been a perpetual fascination for linguists of all persuasions, but a unified account of it has proven elusive. In this paper, I propose a figure-ground gestalt (FGG) hypothesis, arguing that markedness is a mechanism for ...
Chen Rong
doaj   +1 more source

Blind Alley Developments in Childrens’ Language Acquisition

Encyclopedia
A blind alley development (BAD) is a rarely occurring ephemeral development of young children that systematically deviates from parental input and is eventually abandoned due to persistent explicit and/or implicit correction by the children’s caregivers.
Wolfgang U. Dressler
doaj   +1 more source

The phonological dimension of grammatical markedness

, 2006
UnrestrictedThis dissertation explores the correlation between grammatical markedness and the phonological properties of outputs inflected for morpho-syntactic categories on a grammatical markedness hierarchy. The main claim made in the thesis is that,
Iscrulescu, C., Iscrulescu, Cristian
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Choice of classifier handshape in Catalan Sign Language: A corpus study

Open Linguistics
Classifier predicates are sign language modality specific constructions that are widely spread in all attested sign languages. Extended research has been devoted to the study of these structures, but many aspects related to their nature remain unclear ...
Zorzi Giorgia, Veiga Busto Raquel, Barberà Gemma, Navarrete-González Alexandra, Quer Josep   +4 more
doaj   +1 more source

Phonological Markedness and Distinctive Features

, 1983
Phonological Markedness and Distinctive Features establishes a new set of parameters for use in phonological studies of language . Arthur Brakel finds the exciting well-known approaches to phonological description overly elaborate but at the same time ...
Brakel, Arthur
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