Results 81 to 90 of about 83,077 (292)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Marker‐assisted selection in cattle
Animal Biotechnology, 1992 Abstract Direct observation of genetic differences using molecular techniques has prompted investigation into the nature and amount of genetic variation in cattle. Utilization of molecular data will include parentage analysis, individual identification, sexing of embryos and clones and detection of genetic defects.
openaire +1 more source
FishesWalleye Sander vitreus is a valued sportfish in eastern North America, including the upper New River of Virginia, where individuals can grow to a large size (>7 kg).
Sheila Harris +4 more
doaj +1 more source
Genetic bases of tomatо marker-assisted selection in Belarus
The EuroBiotech Journal, 2018 To develop tomato hybrids and varieties with a high fruit quality, we gradually solved the following tasks: development of DNA-marking methods for long shelf life genes; the genes modifying the biosynthesis of carotenoids and their composition; testing ...
Babak Olga G. +4 more
doaj +1 more source
Multivariate approach to endogamy and phenotypic value using different crossbreeding strategies
Pesquisa Agropecuária Tropical, 2014 Simulation has contributed to the advance of genetic improvement. This study aimed at evaluating selective mating by using the distribution of extremes to maximize the phenotypic increment and slow down the endogamy increment, under a multivariate ...
Marcelo Jangarelli
doaj +1 more source
Marker-Assisted Selection for Disease Resistance in Wheat and Barley Breeding [PDF]
, 2012 Thomas Miedaner, Viktor Korzun
openalex +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Вавиловский журнал генетики и селекции, 2014 Over the past decades, wide theoretical and practical experience has been obtained in application of DNA markers for investigation of plant genetic diversity, construction of molecular genetic maps, mapping of genes and quantitative trait loci, and ...
I. N. Leonova
doaj
Breeding for robustness: the role of cortisol*
Animal, 2011 Robustness in farm animals was defined by Knap as ‘the ability to combine a high production potential with resilience to stressors, allowing for unproblematic expression of a high production potential in a wide variety of environmental conditions’.
P. Mormède +3 more
doaj +1 more source