Results 101 to 110 of about 269,710 (304)
Knowledge database assisted gene marker selection for chronic lymphocytic leukemia
Journal of International Medical Research, 2018 Objective To investigate whether previously curated chronic lymphocytic leukemia (CLL) risk genes could be leveraged in gene marker selection for the diagnosis and prediction of CLL.
Xixi Xiang +3 more
doaj +1 more source
Marker assisted selection ‐ an overview
Animal Biotechnology, 1994 Abstract The main force driving gene mapping in domestic animals, is the potential for using gene maps as a means of identifying and mapping the genetic loci responsible for genetic variation in traits of economic importance. The ultimate objective is utilizing this information for marker‐assisted selection (MAS) using DNA level polymorphisms.
openaire +1 more source
G3: Genes, Genomes, Genetics, 2015 Rust is a major pathogen of the peanut crop. Development and adoption of rust-resistant cultivars is the most cost efficient and effective way to control the spread of the disease and reduce yield losses.
S. Leal‐Bertioli +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
BMC Genomics, 2015 Molecular marker-assisted breeding provides an efficient tool to develop improved crop varieties. A major challenge for the broad application of markers in marker-assisted selection is that the marker phenotypes must match plant phenotypes in a wide ...
Huaan Yang +7 more
semanticscholar +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Simulation of marker-assisted recurrent selection in autogamous species
Crop Breeding and Applied Biotechnology, 2002 This work used computer simulation to evaluate marker-assisted selection (MAS) in recurrent selection of autogamous species. Base populations were simulated by crossing each of five inbred lines with two others.
Eduardo Bearzoti, Roland Vencovsky
doaj
Simulation of marker assisted selection in hybrid populations
Genetical Research, 1994 SummaryA computer model is developed that simulates Marker Assisted Selection (MAS) in a population produced by a cross between two inbred lines. Selection is based on an index that incorporates both phenotypic and molecular information. Molecular markers contributing to the index and their relative weights are determined by multiple regression of ...
A, Gimelfarb, R, Lande
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Marker‐assisted selection in cattle
Animal Biotechnology, 1992 Abstract Direct observation of genetic differences using molecular techniques has prompted investigation into the nature and amount of genetic variation in cattle. Utilization of molecular data will include parentage analysis, individual identification, sexing of embryos and clones and detection of genetic defects.
openaire +1 more source